Open your ring: Aluminum salalen complexes are used to initiate the ring-opening polymerization (ROP) of rac-lactide (LA). The reaction pathway of the LA isomers was elucidated by a detailed computational study, which revealed that small changes in the catalytic “bag” implicate the change in induced tacticity (see scheme; PLA= polylactide).
Vieira, I. D. S., Whitelaw, E. L., Jones, M. D., & Herres-Pawlis, S. (2013). Synergistic empirical and theoretical study on the stereoselective mechanism for the aluminum salalen complex mediated polymerization of rac-Lactide. Chemistry - A European Journal, 19(15), 4712-4716. https://doi.org/10.1002/chem.201203973