TY - JOUR
T1 - Swatting flies: modelling wound healing and inflammation in Drosophila
AU - Razzell, W
AU - Wood, William
AU - Martin, P
PY - 2011/9
Y1 - 2011/9
N2 - Aberrant wound healing can lead to a variety of human pathologies, from non-healing chronic wounds that can become dangerously infected, to exuberant fibrotic healing in which repair is accompanied by excessive inflammation. To guide therapeutic intervention, we need a better understanding of the fundamental mechanisms driving tissue repair; this will require complementary wound-healing studies in several model organisms. Drosophila has been used to model genetic aspects of numerous human pathologies, and is being used increasingly to gain insight into the molecular and genetic aspects of tissue repair and inflammation, which have classically been modelled in mice or cultured cells. This review discusses the advantages and disadvantages of Drosophila as a wound-healing model, as well as some exciting new research opportunities that will be enabled by its use.
AB - Aberrant wound healing can lead to a variety of human pathologies, from non-healing chronic wounds that can become dangerously infected, to exuberant fibrotic healing in which repair is accompanied by excessive inflammation. To guide therapeutic intervention, we need a better understanding of the fundamental mechanisms driving tissue repair; this will require complementary wound-healing studies in several model organisms. Drosophila has been used to model genetic aspects of numerous human pathologies, and is being used increasingly to gain insight into the molecular and genetic aspects of tissue repair and inflammation, which have classically been modelled in mice or cultured cells. This review discusses the advantages and disadvantages of Drosophila as a wound-healing model, as well as some exciting new research opportunities that will be enabled by its use.
UR - http://www.scopus.com/inward/record.url?scp=80052300627&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1242/dmm.006825
U2 - 10.1242/dmm.006825
DO - 10.1242/dmm.006825
M3 - Article
SN - 1754-8403
VL - 4
SP - 569
EP - 574
JO - Disease Models and Mechanisms
JF - Disease Models and Mechanisms
IS - 5
ER -