Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure

Xujun Wu; Matthew D Jones; Matthew G Davidson; Julian B Chaudhuri; Marianne J Ellis

doi:10.1007/s10529-010-0438-y

Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure

Xujun Wu, Matthew D Jones, Matthew G Davidson, Julian B Chaudhuri, Marianne J Ellis

Research output: Contribution to journal › Article › peer-review

16 Citations (SciVal)

281 Downloads (Pure)

Abstract

One-step surfactant-free, water-droplet templating has been developed as a fabrication method for a poly(lactide-co-glycolide) (PLGA) film that can be used as a model to investigate the relationship between solvent, monomer ratio, polymer concentration and humidity on its structure. The resulting material is a honeycomb-structured film. Formation of this structure was highly sensitive to solvent, monomer ratio, polymer concentration and humidity. Surfactant-free, water-droplet templating thus allows investigation of fabrication parameters and that PLGA monomer ratio selection is important for scaffold structure but not for MG63 cell attachment and proliferation.

Original language	English
Pages (from-to)	423-430
Number of pages	8
Journal	Biotechnology Letters
Volume	33
Issue number	2
Early online date	20 Oct 2010
DOIs	https://doi.org/10.1007/s10529-010-0438-y
Publication status	Published - Feb 2011

Access to Document

10.1007/s10529-010-0438-y

Author's accepted version
This is a post-peer-review, pre-copyedit version of an article published in Biotechnology Letters. The final authenticated version is available online at: https://doi.org/10.1007/s10529-010-0438-y
Accepted author manuscript, 560 KB

Cite this

@article{22da1dc92d4d4ac79c8e0829e84754c5,

title = "Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure",

abstract = "One-step surfactant-free, water-droplet templating has been developed as a fabrication method for a poly(lactide-co-glycolide) (PLGA) film that can be used as a model to investigate the relationship between solvent, monomer ratio, polymer concentration and humidity on its structure. The resulting material is a honeycomb-structured film. Formation of this structure was highly sensitive to solvent, monomer ratio, polymer concentration and humidity. Surfactant-free, water-droplet templating thus allows investigation of fabrication parameters and that PLGA monomer ratio selection is important for scaffold structure but not for MG63 cell attachment and proliferation.",

author = "Xujun Wu and Jones, \{Matthew D\} and Davidson, \{Matthew G\} and Chaudhuri, \{Julian B\} and Ellis, \{Marianne J\}",

year = "2011",

month = feb,

doi = "10.1007/s10529-010-0438-y",

language = "English",

volume = "33",

pages = "423--430",

journal = "Biotechnology Letters",

issn = "0141-5492",

publisher = "Springer Science and Business Media B.V.",

number = "2",

}

TY - JOUR

T1 - Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure

AU - Wu, Xujun

AU - Jones, Matthew D

AU - Davidson, Matthew G

AU - Chaudhuri, Julian B

AU - Ellis, Marianne J

PY - 2011/2

Y1 - 2011/2

N2 - One-step surfactant-free, water-droplet templating has been developed as a fabrication method for a poly(lactide-co-glycolide) (PLGA) film that can be used as a model to investigate the relationship between solvent, monomer ratio, polymer concentration and humidity on its structure. The resulting material is a honeycomb-structured film. Formation of this structure was highly sensitive to solvent, monomer ratio, polymer concentration and humidity. Surfactant-free, water-droplet templating thus allows investigation of fabrication parameters and that PLGA monomer ratio selection is important for scaffold structure but not for MG63 cell attachment and proliferation.

AB - One-step surfactant-free, water-droplet templating has been developed as a fabrication method for a poly(lactide-co-glycolide) (PLGA) film that can be used as a model to investigate the relationship between solvent, monomer ratio, polymer concentration and humidity on its structure. The resulting material is a honeycomb-structured film. Formation of this structure was highly sensitive to solvent, monomer ratio, polymer concentration and humidity. Surfactant-free, water-droplet templating thus allows investigation of fabrication parameters and that PLGA monomer ratio selection is important for scaffold structure but not for MG63 cell attachment and proliferation.

UR - https://www.scopus.com/pages/publications/78651468094

UR - http://dx.doi.org/10.1007/s10529-010-0438-y

U2 - 10.1007/s10529-010-0438-y

DO - 10.1007/s10529-010-0438-y

M3 - Article

SN - 0141-5492

VL - 33

SP - 423

EP - 430

JO - Biotechnology Letters

JF - Biotechnology Letters

IS - 2

ER -

Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure

Abstract

Access to Document

Other files and links

Fingerprint

Cite this