TY - JOUR
T1 - Surfactant-free poly(lactide-co-glycolide) honeycomb films for tissue engineering: relating solvent, monomer ratio and humidity to scaffold structure
AU - Wu, Xujun
AU - Jones, Matthew D
AU - Davidson, Matthew G
AU - Chaudhuri, Julian B
AU - Ellis, Marianne J
PY - 2011/2
Y1 - 2011/2
N2 - One-step surfactant-free, water-droplet templating has been developed as a fabrication method for a poly(lactide-co-glycolide) (PLGA) film that can be used as a model to investigate the relationship between solvent, monomer ratio, polymer concentration and humidity on its structure. The resulting material is a honeycomb-structured film. Formation of this structure was highly sensitive to solvent, monomer ratio, polymer concentration and humidity. Surfactant-free, water-droplet templating thus allows investigation of fabrication parameters and that PLGA monomer ratio selection is important for scaffold structure but not for MG63 cell attachment and proliferation.
AB - One-step surfactant-free, water-droplet templating has been developed as a fabrication method for a poly(lactide-co-glycolide) (PLGA) film that can be used as a model to investigate the relationship between solvent, monomer ratio, polymer concentration and humidity on its structure. The resulting material is a honeycomb-structured film. Formation of this structure was highly sensitive to solvent, monomer ratio, polymer concentration and humidity. Surfactant-free, water-droplet templating thus allows investigation of fabrication parameters and that PLGA monomer ratio selection is important for scaffold structure but not for MG63 cell attachment and proliferation.
UR - http://www.scopus.com/inward/record.url?scp=78651468094&partnerID=8YFLogxK
UR - http://dx.doi.org/10.1007/s10529-010-0438-y
U2 - 10.1007/s10529-010-0438-y
DO - 10.1007/s10529-010-0438-y
M3 - Article
SN - 0141-5492
VL - 33
SP - 423
EP - 430
JO - Biotechnology Letters
JF - Biotechnology Letters
IS - 2
ER -