Surface-enhanced Raman spectroscopy for bioanalysis and diagnosis

Muhammad Ali Tahir, Nicoleta E. Dina, Hanyun Cheng, Ventsislav K. Valev, Liwu Zhang

Research output: Contribution to journalReview articlepeer-review

3 Citations (SciVal)


In recent years, bioanalytical surface-enhanced Raman spectroscopy (SERS) has blossomed into a fast-growing research area. Owing to its high sensitivity and outstanding multiplexing ability, SERS is an effective analytical technique that has excellent potential in bioanalysis and diagnosis, as demonstrated by its increasing applications in vivo. SERS allows the rapid detection of molecular species based on direct and indirect strategies. Because it benefits from the tunable surface properties of nanostructures, it finds a broad range of applications with clinical relevance, such as biological sensing, drug delivery and live cell imaging assays. Of particular interest are early-stage-cancer detection and the fast detection of pathogens. Here, we present a comprehensive survey of SERS-based assays, from basic considerations to bioanalytical applications. Our main focus is on SERS-based pathogen detection methods as point-of-care solutions for early bacterial infection detection and chronic disease diagnosis. Additionally, various promising in vivo applications of SERS are surveyed. Furthermore, we provide a brief outlook of recent endeavours and we discuss future prospects and limitations for SERS, as a reliable approach for rapid and sensitive bioanalysis and diagnosis.

Original languageEnglish
Pages (from-to)11593-11634
Number of pages42
Issue number27
Early online date6 Jul 2021
Publication statusPublished - 21 Jul 2021

ASJC Scopus subject areas

  • Materials Science(all)


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