Abstract
A supramolecular, polymer-dot-based ensemble has been developed for the ratiometric detection of lectins and targeted delivery of glycoprobes. Self-assembly between a blueemitting polymer dot and a red-emitting glycoprobe, results in an ensemble that shows red emission upon excitation of the polymer dot because of Forster resonance energy transfer. Resulting in ratiometric detection of lectins in buffer solution as well as targeted delivery of the glycoprobe to cells that highly express a sugar receptor. Unlike conventional systems where both the agent and vector are codelivered intracellularly, our ensemble developed here shows a receptor-controlled dissociation on the cell membrane.
Original language | English |
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Pages (from-to) | 3272-3276 |
Number of pages | 5 |
Journal | ACS Applied Materials and Interfaces |
Volume | 9 |
Issue number | 4 |
Early online date | 17 Jan 2017 |
DOIs | |
Publication status | Published - 1 Feb 2017 |
Keywords
- Cell imaging
- Glycoprobe
- Polymer dot
- Probe
- Ratiometric