Supramolecular polymer dot ensemble for ratiometric detection of lectins and targeted delivery of imaging agents

Chang Zheng Wang, Jia Li Chen, Ying Tang, Yi Zang, Guo Rong Chen, Tony D. James, Jia Li, Changfeng Wu, Xiao Peng He

Research output: Contribution to journalArticle

10 Citations (Scopus)
160 Downloads (Pure)

Abstract

A supramolecular, polymer-dot-based ensemble has been developed for the ratiometric detection of lectins and targeted delivery of glycoprobes. Self-assembly between a blueemitting polymer dot and a red-emitting glycoprobe, results in an ensemble that shows red emission upon excitation of the polymer dot because of Forster resonance energy transfer. Resulting in ratiometric detection of lectins in buffer solution as well as targeted delivery of the glycoprobe to cells that highly express a sugar receptor. Unlike conventional systems where both the agent and vector are codelivered intracellularly, our ensemble developed here shows a receptor-controlled dissociation on the cell membrane.

Original languageEnglish
Pages (from-to)3272-3276
Number of pages5
JournalACS Applied Materials and Interfaces
Volume9
Issue number4
Early online date17 Jan 2017
DOIs
Publication statusPublished - 1 Feb 2017

Keywords

  • Cell imaging
  • Glycoprobe
  • Polymer dot
  • Probe
  • Ratiometric

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