Superantigens as immunomodulators: Recent structural insights

Anatassios C. Papageorgiou, K. Ravi Acharya

Research output: Contribution to journalReview article

36 Citations (Scopus)

Abstract

Superantigens interact with major histocompatibility complex (MHC) class II molecules and T-cell receptors (TcRs) forming a trimolecular complex which is able to induce proliferation and cytokine production in T cells. Although superantigens appear to act through a common mechanism, they vary in many of their specific interactions and biological properties. X-ray crystallographic studies and biochemical experiments have now established that cross-linking of MHC class II molecules and the TcR by superantigens can occur in a number of different modes.

Original languageEnglish
Pages (from-to)991-996
Number of pages6
JournalStructure
Volume5
Issue number8
DOIs
Publication statusPublished - 15 Aug 1997

ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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