Sucrose ingestion after exhaustive exercise accelerates liver, but not muscle glycogen repletion when compared to glucose ingestion in trained athletes

Cas Fuchs, Javier Gonzalez, M Beelen, Naomi Cermak, Fiona Smith, Pete Thelwall, Roy Taylor, Michael Trenell, E Stevenson, L J C van Loon

Research output: Contribution to journalArticle

  • 10 Citations

Abstract

Purpose: To assess the effects of sucrose versus glucose ingestion on post-exercise liver and muscle glycogen repletion. Methods: Fifteen well-trained male cyclists completed 2 test days. Each test day started with glycogen-depleting exercise, followed by 5 h of recovery, during which subjects ingested 1.5 g·kg⁻¹·h⁻¹ sucrose or glucose. Blood was sampled frequently and 13C magnetic resonance spectroscopy and imaging were employed 0, 120, and 300 min post-exercise to determine liver and muscle glycogen concentrations and liver volume. Results: Post-exercise muscle glycogen concentrations increased significantly from 85±27 vs 86±35 mmol·L-1 to 140±23 vs 136±26 mmol·L-1 following sucrose and glucose ingestion, respectively (no differences between treatments: P=0.673). Post-exercise liver glycogen concentrations increased significantly from 183±47 vs 167±65 mmol·L-1 to 280±72 vs 234±81 mmol·L-1 following sucrose and glucose ingestion, respectively (time x treatment, P=0.051). Liver volume increased significantly over the 300 min period after sucrose ingestion only (time x treatment, P=0.001). As a result, total liver glycogen content increased during post-exercise recovery to a greater extent in the sucrose treatment (from 53.6±16.2 to 86.8±29.0 g) compared to the glucose treatment (49.3±25.5 to 65.7±27.1 g; time x treatment, P<0.001), equating to a 3.4 g·h-1 (95%CI: 1.6 to 5.1 g·h-1) greater repletion rate with sucrose vs glucose ingestion. Conclusion: Sucrose ingestion (1.5 g·kg-1·h-1) further accelerates post-exercise liver, but not muscle glycogen repletion when compared to glucose ingestion in trained athletes.This trial was registered at clinicaltrials.gov as NCT02344381.
LanguageEnglish
Pages1328-1334
Number of pages29
JournalJournal of Applied Physiology
Volume120
Issue number11
Early online date24 Mar 2016
DOIs
StatusPublished - 1 Jun 2016

Fingerprint

Glycogen
Athletes
Sucrose
Eating
Exercise
Glucose
Muscles
Liver Glycogen
Liver
Therapeutics
Magnetic Resonance Spectroscopy
Magnetic Resonance Imaging

Keywords

  • 13C magnetic resonance spectroscopy
  • carbohydrate
  • recovery
  • fructose
  • endurance exercise

Cite this

Sucrose ingestion after exhaustive exercise accelerates liver, but not muscle glycogen repletion when compared to glucose ingestion in trained athletes. / Fuchs, Cas; Gonzalez, Javier; Beelen, M; Cermak, Naomi; Smith, Fiona; Thelwall, Pete; Taylor, Roy; Trenell, Michael; Stevenson, E; van Loon, L J C.

In: Journal of Applied Physiology, Vol. 120, No. 11, 01.06.2016, p. 1328-1334.

Research output: Contribution to journalArticle

Fuchs, C, Gonzalez, J, Beelen, M, Cermak, N, Smith, F, Thelwall, P, Taylor, R, Trenell, M, Stevenson, E & van Loon, LJC 2016, 'Sucrose ingestion after exhaustive exercise accelerates liver, but not muscle glycogen repletion when compared to glucose ingestion in trained athletes' Journal of Applied Physiology, vol. 120, no. 11, pp. 1328-1334. DOI: 10.1152/japplphysiol.01023.2015
Fuchs, Cas ; Gonzalez, Javier ; Beelen, M ; Cermak, Naomi ; Smith, Fiona ; Thelwall, Pete ; Taylor, Roy ; Trenell, Michael ; Stevenson, E ; van Loon, L J C. / Sucrose ingestion after exhaustive exercise accelerates liver, but not muscle glycogen repletion when compared to glucose ingestion in trained athletes. In: Journal of Applied Physiology. 2016 ; Vol. 120, No. 11. pp. 1328-1334
@article{ee99ba3ad5654e31bb3c40aefa080dac,
title = "Sucrose ingestion after exhaustive exercise accelerates liver, but not muscle glycogen repletion when compared to glucose ingestion in trained athletes",
abstract = "Purpose: To assess the effects of sucrose versus glucose ingestion on post-exercise liver and muscle glycogen repletion. Methods: Fifteen well-trained male cyclists completed 2 test days. Each test day started with glycogen-depleting exercise, followed by 5 h of recovery, during which subjects ingested 1.5 g·kg⁻¹·h⁻¹ sucrose or glucose. Blood was sampled frequently and 13C magnetic resonance spectroscopy and imaging were employed 0, 120, and 300 min post-exercise to determine liver and muscle glycogen concentrations and liver volume. Results: Post-exercise muscle glycogen concentrations increased significantly from 85±27 vs 86±35 mmol·L-1 to 140±23 vs 136±26 mmol·L-1 following sucrose and glucose ingestion, respectively (no differences between treatments: P=0.673). Post-exercise liver glycogen concentrations increased significantly from 183±47 vs 167±65 mmol·L-1 to 280±72 vs 234±81 mmol·L-1 following sucrose and glucose ingestion, respectively (time x treatment, P=0.051). Liver volume increased significantly over the 300 min period after sucrose ingestion only (time x treatment, P=0.001). As a result, total liver glycogen content increased during post-exercise recovery to a greater extent in the sucrose treatment (from 53.6±16.2 to 86.8±29.0 g) compared to the glucose treatment (49.3±25.5 to 65.7±27.1 g; time x treatment, P<0.001), equating to a 3.4 g·h-1 (95{\%}CI: 1.6 to 5.1 g·h-1) greater repletion rate with sucrose vs glucose ingestion. Conclusion: Sucrose ingestion (1.5 g·kg-1·h-1) further accelerates post-exercise liver, but not muscle glycogen repletion when compared to glucose ingestion in trained athletes.This trial was registered at clinicaltrials.gov as NCT02344381.",
keywords = "13C magnetic resonance spectroscopy, carbohydrate, recovery, fructose, endurance exercise",
author = "Cas Fuchs and Javier Gonzalez and M Beelen and Naomi Cermak and Fiona Smith and Pete Thelwall and Roy Taylor and Michael Trenell and E Stevenson and {van Loon}, {L J C}",
year = "2016",
month = "6",
day = "1",
doi = "10.1152/japplphysiol.01023.2015",
language = "English",
volume = "120",
pages = "1328--1334",
journal = "Journal of Applied Physiology",
issn = "0161-7567",
publisher = "American Physiological Society",
number = "11",

}

TY - JOUR

T1 - Sucrose ingestion after exhaustive exercise accelerates liver, but not muscle glycogen repletion when compared to glucose ingestion in trained athletes

AU - Fuchs,Cas

AU - Gonzalez,Javier

AU - Beelen,M

AU - Cermak,Naomi

AU - Smith,Fiona

AU - Thelwall,Pete

AU - Taylor,Roy

AU - Trenell,Michael

AU - Stevenson,E

AU - van Loon,L J C

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Purpose: To assess the effects of sucrose versus glucose ingestion on post-exercise liver and muscle glycogen repletion. Methods: Fifteen well-trained male cyclists completed 2 test days. Each test day started with glycogen-depleting exercise, followed by 5 h of recovery, during which subjects ingested 1.5 g·kg⁻¹·h⁻¹ sucrose or glucose. Blood was sampled frequently and 13C magnetic resonance spectroscopy and imaging were employed 0, 120, and 300 min post-exercise to determine liver and muscle glycogen concentrations and liver volume. Results: Post-exercise muscle glycogen concentrations increased significantly from 85±27 vs 86±35 mmol·L-1 to 140±23 vs 136±26 mmol·L-1 following sucrose and glucose ingestion, respectively (no differences between treatments: P=0.673). Post-exercise liver glycogen concentrations increased significantly from 183±47 vs 167±65 mmol·L-1 to 280±72 vs 234±81 mmol·L-1 following sucrose and glucose ingestion, respectively (time x treatment, P=0.051). Liver volume increased significantly over the 300 min period after sucrose ingestion only (time x treatment, P=0.001). As a result, total liver glycogen content increased during post-exercise recovery to a greater extent in the sucrose treatment (from 53.6±16.2 to 86.8±29.0 g) compared to the glucose treatment (49.3±25.5 to 65.7±27.1 g; time x treatment, P<0.001), equating to a 3.4 g·h-1 (95%CI: 1.6 to 5.1 g·h-1) greater repletion rate with sucrose vs glucose ingestion. Conclusion: Sucrose ingestion (1.5 g·kg-1·h-1) further accelerates post-exercise liver, but not muscle glycogen repletion when compared to glucose ingestion in trained athletes.This trial was registered at clinicaltrials.gov as NCT02344381.

AB - Purpose: To assess the effects of sucrose versus glucose ingestion on post-exercise liver and muscle glycogen repletion. Methods: Fifteen well-trained male cyclists completed 2 test days. Each test day started with glycogen-depleting exercise, followed by 5 h of recovery, during which subjects ingested 1.5 g·kg⁻¹·h⁻¹ sucrose or glucose. Blood was sampled frequently and 13C magnetic resonance spectroscopy and imaging were employed 0, 120, and 300 min post-exercise to determine liver and muscle glycogen concentrations and liver volume. Results: Post-exercise muscle glycogen concentrations increased significantly from 85±27 vs 86±35 mmol·L-1 to 140±23 vs 136±26 mmol·L-1 following sucrose and glucose ingestion, respectively (no differences between treatments: P=0.673). Post-exercise liver glycogen concentrations increased significantly from 183±47 vs 167±65 mmol·L-1 to 280±72 vs 234±81 mmol·L-1 following sucrose and glucose ingestion, respectively (time x treatment, P=0.051). Liver volume increased significantly over the 300 min period after sucrose ingestion only (time x treatment, P=0.001). As a result, total liver glycogen content increased during post-exercise recovery to a greater extent in the sucrose treatment (from 53.6±16.2 to 86.8±29.0 g) compared to the glucose treatment (49.3±25.5 to 65.7±27.1 g; time x treatment, P<0.001), equating to a 3.4 g·h-1 (95%CI: 1.6 to 5.1 g·h-1) greater repletion rate with sucrose vs glucose ingestion. Conclusion: Sucrose ingestion (1.5 g·kg-1·h-1) further accelerates post-exercise liver, but not muscle glycogen repletion when compared to glucose ingestion in trained athletes.This trial was registered at clinicaltrials.gov as NCT02344381.

KW - 13C magnetic resonance spectroscopy

KW - carbohydrate

KW - recovery

KW - fructose

KW - endurance exercise

UR - http://dx.doi.org/10.1152/japplphysiol.01023.2015

U2 - 10.1152/japplphysiol.01023.2015

DO - 10.1152/japplphysiol.01023.2015

M3 - Article

VL - 120

SP - 1328

EP - 1334

JO - Journal of Applied Physiology

T2 - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 0161-7567

IS - 11

ER -