Substrate analogue studies on clavaminic acid synthase

Jack E. Baldwin; Victor Lee; Matthew D. Lloyd; Christopher J. Schofield; Stephen W. Elson; Keith H. Baggaley

doi:10.1039/c39930001694

Substrate analogue studies on clavaminic acid synthase

Jack E. Baldwin, Victor Lee, Matthew D. Lloyd, Christopher J. Schofield, Stephen W. Elson, Keith H. Baggaley

Department of Life Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Incubation of N-α-acetyl-L-ornithine with clavaminic acid synthase led to the isolation of (E)-(2S)-5-amino-2-acetamidopent-3-enoic acid and (2S)-2-acetamido-5-amino-3-hydroxypentanoic acid, while incubation of N-α-acetyl-L-arginine led to the isolation of (2S)-2-acetamido-5-guanidino-3-hydroxypentanoic acid.

Original language	English
Pages (from-to)	1694-1696
Journal	Journal of the Chemical Society, Chemical Communications
Issue number	22
DOIs	https://doi.org/10.1039/c39930001694
Publication status	Published - 1993

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title = "Substrate analogue studies on clavaminic acid synthase",

abstract = "Incubation of N-α-acetyl-L-ornithine with clavaminic acid synthase led to the isolation of (E)-(2S)-5-amino-2-acetamidopent-3-enoic acid and (2S)-2-acetamido-5-amino-3-hydroxypentanoic acid, while incubation of N-α-acetyl-L-arginine led to the isolation of (2S)-2-acetamido-5-guanidino-3-hydroxypentanoic acid. ",

author = "Baldwin, \{Jack E.\} and Victor Lee and Lloyd, \{Matthew D.\} and Schofield, \{Christopher J.\} and Elson, \{Stephen W.\} and Baggaley, \{Keith H.\}",

year = "1993",

doi = "10.1039/c39930001694",

language = "English",

pages = "1694--1696",

journal = "Journal of the Chemical Society, Chemical Communications",

issn = "0022-4936",

publisher = "Chemical Society",

number = "22",

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TY - JOUR

T1 - Substrate analogue studies on clavaminic acid synthase

AU - Baldwin, Jack E.

AU - Lee, Victor

AU - Lloyd, Matthew D.

AU - Schofield, Christopher J.

AU - Elson, Stephen W.

AU - Baggaley, Keith H.

PY - 1993

Y1 - 1993

N2 - Incubation of N-α-acetyl-L-ornithine with clavaminic acid synthase led to the isolation of (E)-(2S)-5-amino-2-acetamidopent-3-enoic acid and (2S)-2-acetamido-5-amino-3-hydroxypentanoic acid, while incubation of N-α-acetyl-L-arginine led to the isolation of (2S)-2-acetamido-5-guanidino-3-hydroxypentanoic acid.

AB - Incubation of N-α-acetyl-L-ornithine with clavaminic acid synthase led to the isolation of (E)-(2S)-5-amino-2-acetamidopent-3-enoic acid and (2S)-2-acetamido-5-amino-3-hydroxypentanoic acid, while incubation of N-α-acetyl-L-arginine led to the isolation of (2S)-2-acetamido-5-guanidino-3-hydroxypentanoic acid.

UR - http://xlink.rsc.org/?DOI=c39930001694

UR - http://dx.doi.org/10.1039/c39930001694

UR - https://www.scopus.com/pages/publications/0027360462

U2 - 10.1039/c39930001694

DO - 10.1039/c39930001694

M3 - Article

SN - 0022-4936

SP - 1694

EP - 1696

JO - Journal of the Chemical Society, Chemical Communications

JF - Journal of the Chemical Society, Chemical Communications

IS - 22

ER -

Substrate analogue studies on clavaminic acid synthase

Abstract

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