STX140 and STX641 cause apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells

Paul A. Foster, Yaik T. Ho, Simon P. Newman, Mathew P. Leese, Barry V. L. Potter, Michael J. Reed, Atul Purohit

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)

Abstract

Many anticancer drugs target microtubules and induce apoptosis. However, improved microtubule-targeting drugs, such as STX140 and STX641, are being developed. These compounds induce cell cycle arrest and apoptosis in a variety of tumour cells. The mechanisms that induce apoptosis and the key mediators involved are elucidated in this study. Results demonstrate that STX140 and STX641 depolarise mitochondrial bioenergetics and activate caspase 3/7 in A2780, LNCaP and MCF-7 cancer cells. Furthermore, both compounds cause a significant reduction in the expression of survivin and XIAP. This work details the temporal organisation of apoptosis induced by two microtubule disruptors and highlights the role that the down-regulation of survivin and XIAP may play in this process.
Original languageEnglish
Pages (from-to)3751-3757
Number of pages7
JournalAnticancer Research
Volume29
Issue number10
Publication statusPublished - Oct 2009

Fingerprint Dive into the research topics of 'STX140 and STX641 cause apoptosis via the intrinsic mitochondrial pathway and down-regulate survivin and XIAP expression in ovarian and prostate cancer cells'. Together they form a unique fingerprint.

Cite this