Studying the neural bases of prism adaptation using fMRI: a technical and design challenge

Janet Bultitude, Alessandro Farnè, Romeo Salemme, Danielle Ibarrola, Christian Urquizar, Jacinta O'Shea, Jacques Luauté

Research output: Contribution to journalArticle

Abstract

Prism adaptation induces rapid recalibration of visuomotor coordination. The neural mechanisms of prism adaptation have come under scrutiny since the observations that the technique can alleviate hemispatial neglect following stroke, and can alter spatial cognition in healthy controls. Relative to non-imaging behavioral studies, fMRI investigations of prism adaptation face several challenges arising from the confined physical environment of the scanner and the supine position of the participants. Any researcher who wishes to administer prism adaptation in an fMRI environment must adjust their procedures enough to enable the experiment to be performed, but not so much that the behavioral task departs too much from true prism adaptation. Furthermore, the specific temporal dynamics of behavioral components of prism adaptation present additional challenges for measuring their neural correlates. We developed a system for measuring the key features of prism adaptation behavior within an fMRI environment. To validate our configuration, we present behavioral (pointing) and head movement data from 11 right-hemisphere lesioned patients and 17 older controls who underwent sham and real prism adaptation in an MRI scanner. Most participants could adapt to prismatic displacement with minimal head movements, and the procedure was well tolerated. We propose recommendations for fMRI studies of prism adaptation based on the design-specific constraints and our results.
LanguageEnglish
Pages2031–2043
JournalBehavior Research Methods
Volume49
Issue number6
Early online date30 Dec 2016
DOIs
StatusPublished - 1 Dec 2017

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Magnetic Resonance Imaging
Head Movements
Perceptual Disorders
Supine Position
Cognition
Stroke
Research Personnel
Functional Magnetic Resonance Imaging

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Bultitude, J., Farnè, A., Salemme, R., Ibarrola, D., Urquizar, C., O'Shea, J., & Luauté, J. (2017). Studying the neural bases of prism adaptation using fMRI: a technical and design challenge. DOI: 10.3758/s13428-016-0840-z

Studying the neural bases of prism adaptation using fMRI : a technical and design challenge. / Bultitude, Janet; Farnè, Alessandro; Salemme, Romeo; Ibarrola, Danielle; Urquizar, Christian; O'Shea, Jacinta; Luauté, Jacques.

In: Behavior Research Methods, Vol. 49, No. 6, 01.12.2017, p. 2031–2043.

Research output: Contribution to journalArticle

Bultitude, J, Farnè, A, Salemme, R, Ibarrola, D, Urquizar, C, O'Shea, J & Luauté, J 2017, 'Studying the neural bases of prism adaptation using fMRI: a technical and design challenge' Behavior Research Methods, vol. 49, no. 6, pp. 2031–2043. DOI: 10.3758/s13428-016-0840-z
Bultitude J, Farnè A, Salemme R, Ibarrola D, Urquizar C, O'Shea J et al. Studying the neural bases of prism adaptation using fMRI: a technical and design challenge. Behavior Research Methods. 2017 Dec 1;49(6):2031–2043. Available from, DOI: 10.3758/s13428-016-0840-z
Bultitude, Janet ; Farnè, Alessandro ; Salemme, Romeo ; Ibarrola, Danielle ; Urquizar, Christian ; O'Shea, Jacinta ; Luauté, Jacques. / Studying the neural bases of prism adaptation using fMRI : a technical and design challenge. In: Behavior Research Methods. 2017 ; Vol. 49, No. 6. pp. 2031–2043
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