Study protocol of 'Prism Adaptation in Rehabilitation'

Antonia F. Ten Brink, Johanna M. A. Visser-Meily, Tanja C. W. Nijboer

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12 Citations (SciVal)


BACKGROUND: A frequent disorder after stroke is neglect, resulting in a failure to report or respond to contralesional stimuli. Rehabilitation of neglect is important, given the negative influence on motor recovery, independence in self-care, transfers, and locomotion. Effects of prism adaptation (PA) to alleviate neglect have been reported. However, either small groups or no control group were included and few studies reported outcome measurements on the level of activities of daily living (ADL). The current ongoing RCT investigates the short- and long-term effects of PA in a large population in a realistic clinical setting. Measures range from the level of function to the level of ADL.METHODS/DESIGN: Neglect patients in the sub-acute phase after stroke are randomly assigned to PA (n = 35) or sham adaptation (SA; n = 35). Adaptation is performed for 10 consecutive weekdays. Patients are tested at start of the study, 1 and 2 weeks after starting, and 1, 2, 4 and 12 weeks after ending treatment. Primary objectives are changes in performance on neuropsychological tests and neglect in ADL. Secondary objectives are changes in simulated driving, eye movements, balance, visual scanning and mobility, subjective experience of neglect in ADL and independence during ADL.DISCUSSION: If effective, PA could be implemented as a treatment for neglect.TRIAL REGISTRATION: This trial is registered at the Dutch Trial Register # NTR3278 .
Original languageEnglish
Issue number5
Publication statusPublished - 4 Feb 2015


  • Activities of Daily Living
  • Eye Movements
  • Humans
  • Neuropsychological Tests
  • Perceptual Disorders
  • Postural Balance
  • Research Design
  • Stroke Rehabilitation
  • Journal Article
  • Randomized Controlled Trial


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