Structured biodegradable microparticles produced using glass microfluidic flow focussing devices

Ekanem E. Ekanem, Goran T. Vladisavljevic

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Herein is reported the production of biodegradable poly (lactic acid) (PLA) and poly (lactic-coglycolic acid) (PLGA) particles having modifiable internal and surface microstructures via single step emulsification using microfabricated 3D (axisymmetric) flow focusing glass capillary microfluidic devices and subsequent solvent evaporation. Controlled production of emulsion droplets was achieved and the morphology of particles produced after evaporation was investigated to ascertain its effect on hydrophobic drug encapsulation and release.

Original languageEnglish
Title of host publication18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
PublisherChemical and Biological Microsystems Society
Pages971-973
Number of pages3
ISBN (Electronic)9780979806476
Publication statusPublished - 2014
Event18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 - San Antonio, USA United States
Duration: 26 Oct 201430 Oct 2014

Conference

Conference18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014
CountryUSA United States
CitySan Antonio
Period26/10/1430/10/14

Keywords

  • Biodegradable microparticles
  • Drug encapsulation
  • Emulsification
  • Microfluidic devices

ASJC Scopus subject areas

  • Control and Systems Engineering

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  • Cite this

    Ekanem, E. E., & Vladisavljevic, G. T. (2014). Structured biodegradable microparticles produced using glass microfluidic flow focussing devices. In 18th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2014 (pp. 971-973). Chemical and Biological Microsystems Society.