TY - GEN
T1 - Structural elements which govern the resistance of intestinal tissues to compound transport
AU - Rubas, Werner
AU - Cronwell, Mary
AU - Gadek, Tom
AU - Narindray, Daljit
AU - Mrsny, Randy
PY - 1994/12/31
Y1 - 1994/12/31
N2 - The series of cyclized ARGD peptides in this study demonstrated a very low partition into octanol as judged by HPLC. Thus these molecules are likely to move predominantly through the paracellular pathway. Permeability across Caco-2 monolayers was determined using reversed phase HPLCand found to be restricted by molecular weight and possibly charge-charge interactions between the solute and charged moieties within the paracellular shunt. When normalized for molecular weight,molecules with a net charge between -1 and-2 demonstrated the highest permeabilities, which suggests an optimal net charge with respect to permeability.
AB - The series of cyclized ARGD peptides in this study demonstrated a very low partition into octanol as judged by HPLC. Thus these molecules are likely to move predominantly through the paracellular pathway. Permeability across Caco-2 monolayers was determined using reversed phase HPLCand found to be restricted by molecular weight and possibly charge-charge interactions between the solute and charged moieties within the paracellular shunt. When normalized for molecular weight,molecules with a net charge between -1 and-2 demonstrated the highest permeabilities, which suggests an optimal net charge with respect to permeability.
UR - http://www.scopus.com/inward/record.url?scp=0028062263&partnerID=8YFLogxK
M3 - Chapter in a published conference proceeding
AN - SCOPUS:0028062263
SN - 1558992308
T3 - Materials Research Society Symposium Proceedings
SP - 179
EP - 185
BT - Materials Research Society Symposium Proceedings
PB - Publ by Materials Research Society
T2 - Proceedings of the Biomaterials for Drug and Cell Delivery
Y2 - 29 November 1993 through 1 December 1993
ER -