Structural determinants of opioid activity in the orvinols and related structures: Ethers of orvinol and isoorvinol

Andrew Coop, Claire L. Norton, Ilona Berzetei-Gurske, Jackie Burnside, Lawrence Toll, Stephen M. Husbands, John W. Lewis

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11 Citations (Scopus)

Abstract

A series of ethers of orvinol and isoorvinol has been prepared and evaluated in opioid receptor binding and in vitro functional assays. The most striking finding was the very large difference in K-opioid receptor activity between the diastereomeric ethyl ethers: 46-fold in binding, 150-fold in GPI, and 900-fold in the [35S]GTPγS assay in favor of the (R)-diastereomer. Additionally in the (R)-series there was a 700-fold increase in K-agonist potency in the [35S]GTPγS assay when OEt was replaced by OBn. The data can be explained in a triple binding site model: an H-bonding site, a lipophilic site, and an inhibitory site with which the 20-Me group in the (S)-ethers may interact. It appears that K-agonist binding of the orvinols avoids the inhibitory site in the intramolecular H-bonded conformation.

Original languageEnglish
Pages (from-to)1852-1857
Number of pages6
JournalJournal of Medicinal Chemistry
Volume43
Issue number9
DOIs
Publication statusPublished - 1 May 2000

ASJC Scopus subject areas

  • Molecular Medicine
  • Drug Discovery

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