Structural and thermodynamic analysis of a three-component assembly forming ortho-iminophenylboronate esters

Brette M. Chapin, Pedro Metola, Vincent M. Lynch, John F. Stanton, Tony D. James, Eric V. Anslyn

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)
186 Downloads (Pure)

Abstract

Structural studies of a three-component assembly - a host and two distinct guests - were carried out using a combination of 11B and 1H NMR. In aprotic solvent, the imino group that forms ortho to the boronic acid or boronate ester group can form a dative N-B bond. In protic solvent, a molecule of solvent inserts between the nitrogen and boron atoms, partially ionizing the solvent molecule. Additionally, 11B NMR was used in combination with a seventh-order polynomial to calculate five binding constants for each of the individual steps in protic solvent. Comparison of these binding constants was used to establish positive cooperativity in the binding of the two guests.

Original languageEnglish
Pages (from-to)8319-8330
Number of pages12
JournalJournal of Organic Chemistry
Volume81
Issue number18
Early online date2 Sep 2016
DOIs
Publication statusPublished - 16 Sep 2016

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