Abstract
Original language | English |
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Pages (from-to) | 16047-16079 |
Number of pages | 33 |
Journal | ACS OMEGA |
Volume | 8 |
Issue number | 18 |
Early online date | 25 Apr 2023 |
DOIs | |
Publication status | Published - 9 May 2023 |
Bibliographical note
The authors thank the Royal Society, STFC, BBSRC, and MRC for funding (S.I.P.), as well as the EPSRC Crystallography Service (using Daresbury SRS, Diamond DLS and University of Southampton facilities). We also thank the EPSRC for access to the EPR NRF (NS/A000055/1, EP/W014521/1) and the EPSRC UK National Mass Spectrometry Facility at Swansea University for the acquisition of some mass spectra presented in this work. S.I.P., F.C.-T., and H.G. thank the European Commission for the funding through an ERC Consolidator Grant (O2SENSE Program, 2014–2020). F.C.-T. was funded by the European Commission FP7 Programme through the Marie Curie Initial Training Network PROSENSE (grant no. 317420, 2012–2016). The authors thank several previous research undergraduate research students and graduate researchers at Oxford and Bath Universities (especially T. Conry, L. Murray, J. Williams, E. Davis, O. Neil, S. Sarpaki, and G. Williams) for their contributions through helpful discussions and some early stage preliminary experiments. Dr. A. Cowley and Dr. A. Thompson (Oxford University) are thanked for their assistance with some of the earlier X-ray data collection. We also thanks Drs. Helen Betts, and Simon Bayly for assistance with 64Cu radiolabeling experiments and training at Siemens Oxford Molecular Imaging Laboratory (SOMIL). We would like to thank Mr. Paul Burke for generating the copper-64 and to Professor Franklin Aigbirhio for supplying 64Cu to SOMIL. We also thank Professors Franklin Aigbirhio (Wolfson Brain Imaging Centre, University of Cambridge) and Jason Lewis (MSKCC, US) for training in handling 64Cu, collaborative support and mentoring in radiochemistry and Professor Rex Tyrell for training in living cells assays.The data that supports the findings of this study are available in the supplementary material of this article or from the authors.
Funding
The authors thank the Royal Society, STFC, BBSRC, and MRC for funding (S.I.P.), as well as the EPSRC Crystallography Service (using Daresbury SRS, Diamond DLS and University of Southampton facilities). We also thank the EPSRC for access to the EPR NRF (NS/A000055/1, EP/W014521/1) and the EPSRC UK National Mass Spectrometry Facility at Swansea University for the acquisition of some mass spectra presented in this work. S.I.P., F.C.-T., and H.G. thank the European Commission for the funding through an ERC Consolidator Grant (O2SENSE Program, 2014–2020). F.C.-T. was funded by the European Commission FP7 Programme through the Marie Curie Initial Training Network PROSENSE (grant no. 317420, 2012–2016). The authors thank several previous research undergraduate research students and graduate researchers at Oxford and Bath Universities (especially T. Conry, L. Murray, J. Williams, E. Davis, O. Neil, S. Sarpaki, and G. Williams) for their contributions through helpful discussions and some early stage preliminary experiments. Dr. A. Cowley and Dr. A. Thompson (Oxford University) are thanked for their assistance with some of the earlier X-ray data collection. We also thanks Drs. Helen Betts, and Simon Bayly for assistance with Cu radiolabeling experiments and training at Siemens Oxford Molecular Imaging Laboratory (SOMIL). We would like to thank Mr. Paul Burke for generating the copper-64 and to Professor Franklin Aigbirhio for supplying Cu to SOMIL. We also thank Professors Franklin Aigbirhio (Wolfson Brain Imaging Centre, University of Cambridge) and Jason Lewis (MSKCC, US) for training in handling Cu, collaborative support and mentoring in radiochemistry and Professor Rex Tyrell for training in living cells assays. 64 64 64 The authors thank the Royal Society, STFC, BBSRC, and MRC for funding (S.I.P.), as well as the EPSRC Crystallography Service (using Daresbury SRS, Diamond DLS and University of Southampton facilities). We also thank the EPSRC for access to the EPR NRF (NS/A000055/1, EP/W014521/1) and the EPSRC UK National Mass Spectrometry Facility at Swansea University for the acquisition of some mass spectra presented in this work. S.I.P., F.C.-T., and H.G. thank the European Commission for the funding through an ERC Consolidator Grant (O2SENSE Program, 2014-2020). F.C.-T. was funded by the European Commission FP7 Programme through the Marie Curie Initial Training Network PROSENSE (grant no. 317420, 2012-2016). The authors thank several previous research undergraduate research students and graduate researchers at Oxford and Bath Universities (especially T. Conry, L. Murray, J. Williams, E. Davis, O. Neil, S. Sarpaki, and G. Williams) for their contributions through helpful discussions and some early stage preliminary experiments. Dr. A. Cowley and Dr. A. Thompson (Oxford University) are thanked for their assistance with some of the earlier X-ray data collection. We also thanks Drs. Helen Betts, and Simon Bayly for assistance with 64Cu radiolabeling experiments and training at Siemens Oxford Molecular Imaging Laboratory (SOMIL). We would like to thank Mr. Paul Burke for generating the copper-64 and to Professor Franklin Aigbirhio for supplying 64Cu to SOMIL. We also thank Professors Franklin Aigbirhio (Wolfson Brain Imaging Centre, University of Cambridge) and Jason Lewis (MSKCC, US) for training in handling 64Cu, collaborative support and mentoring in radiochemistry and Professor Rex Tyrell for training in living cells assays.
Funders | Funder number |
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EPSRC UK National Mass Spectrometry Facility at Swansea University | |
Wolfson Brain Imaging Centre | |
Medical Research Council | |
Engineering and Physical Sciences Research Council | NS/A000055/1, EP/W014521/1 |
Biotechnology and Biological Sciences Research Council | |
Science and Technology Facilities Council | |
Royal Society | |
University of Cambridge | |
European Commission | 317420 |
European Research Council |