TY - JOUR
T1 - Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates
AU - Iqbal, Aman
AU - Clifton, Ian J.
AU - Chowdhury, Rasheduzzaman
AU - Ivison, David
AU - Domene Nunez, Carmen
AU - Schofield, Christopher J.
PY - 2011/9/1
Y1 - 2011/9/1
N2 - Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.
AB - Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.
KW - SERINE-PROTEASE CATALYSIS, ACYL-ENZYME COMPLEX, CRYSTAL-STRUCTURE, GENE-CLUSTER, ACETYLTRANSFERASE, INTERMEDIATE, MECHANISM
UR - http://dx.doi.org/10.1039/c1ob05554b
UR - https://www.scopus.com/pages/publications/80052236830
U2 - 10.1039/c1ob05554b
DO - 10.1039/c1ob05554b
M3 - Article
SN - 1477-0520
VL - 9
SP - 6219
EP - 6225
JO - Organic and Biomolecular Chemistry
JF - Organic and Biomolecular Chemistry
IS - 18
ER -