Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

Aman Iqbal; Ian J. Clifton; Rasheduzzaman Chowdhury; David Ivison; Carmen Domene Nunez; Christopher J. Schofield

doi:10.1039/c1ob05554b

Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

Aman Iqbal, Ian J. Clifton, Rasheduzzaman Chowdhury, David Ivison, Carmen Domene Nunez, Christopher J. Schofield

Department of Chemistry

University of Oxford

Research output: Contribution to journal › Article › peer-review

4 Citations (SciVal)

Abstract

Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.

Original language	English
Pages (from-to)	6219-6225
Number of pages	7
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	18
DOIs	https://doi.org/10.1039/c1ob05554b
Publication status	Published - 1 Sept 2011

Keywords

SERINE-PROTEASE CATALYSIS, ACYL-ENZYME COMPLEX, CRYSTAL-STRUCTURE, GENE-CLUSTER, ACETYLTRANSFERASE, INTERMEDIATE, MECHANISM

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10.1039/c1ob05554b

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title = "Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates",

abstract = "Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.",

keywords = "SERINE-PROTEASE CATALYSIS, ACYL-ENZYME COMPLEX, CRYSTAL-STRUCTURE, GENE-CLUSTER, ACETYLTRANSFERASE, INTERMEDIATE, MECHANISM",

author = "Aman Iqbal and Clifton, {Ian J.} and Rasheduzzaman Chowdhury and David Ivison and {Domene Nunez}, Carmen and Schofield, {Christopher J.}",

year = "2011",

month = sep,

day = "1",

doi = "10.1039/c1ob05554b",

language = "English",

volume = "9",

pages = "6219--6225",

journal = "Organic and Biomolecular Chemistry",

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TY - JOUR

T1 - Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

AU - Iqbal, Aman

AU - Clifton, Ian J.

AU - Chowdhury, Rasheduzzaman

AU - Ivison, David

AU - Domene Nunez, Carmen

AU - Schofield, Christopher J.

PY - 2011/9/1

Y1 - 2011/9/1

N2 - Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.

AB - Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.

KW - SERINE-PROTEASE CATALYSIS, ACYL-ENZYME COMPLEX, CRYSTAL-STRUCTURE, GENE-CLUSTER, ACETYLTRANSFERASE, INTERMEDIATE, MECHANISM

UR - http://dx.doi.org/10.1039/c1ob05554b

U2 - 10.1039/c1ob05554b

DO - 10.1039/c1ob05554b

M3 - Article

SN - 1477-0520

VL - 9

SP - 6219

EP - 6225

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 18

ER -

Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

Abstract

Keywords

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