Structural and biochemical analyses reveal how ornithine acetyl transferase binds acidic and basic amino acid substrates

Aman Iqbal, Ian J. Clifton, Rasheduzzaman Chowdhury, David Ivison, Carmen Domene Nunez, Christopher J. Schofield

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Structural and biochemical analyses reveal how ornithine acetyl-transferases catalyse the reversible transfer of an acetyl-group from a basic (ornithine) to an acidic (glutamate) amino acid by employing a common mechanism involving an acetyl-enzyme intermediate but using different side chain binding modes.
Original languageEnglish
Pages (from-to)6219-6225
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume9
Issue number18
DOIs
Publication statusPublished - 1 Sep 2011

Keywords

  • SERINE-PROTEASE CATALYSIS, ACYL-ENZYME COMPLEX, CRYSTAL-STRUCTURE, GENE-CLUSTER, ACETYLTRANSFERASE, INTERMEDIATE, MECHANISM

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