Strategies for Multiplexed Electrochemical Sensor Development

Uros Zupancic; Josh Rainbow; Connor Flynn; Josephine Aidoo-Brown; Pedro Estrela; Despina Moschou

doi:10.1007/978-981-15-9612-4_3

Strategies for Multiplexed Electrochemical Sensor Development

Uros Zupancic, Josh Rainbow, Connor Flynn, Josephine Aidoo-Brown, Pedro Estrela, Despina Moschou

University of New Brunswick

Research output: Chapter or section in a book/report/conference proceeding › Chapter or section

9 Citations (SciVal)

307 Downloads (Pure)

Abstract

Detection of multiple biomarkers for disease diagnosis or treatment monitoring has received a lot of attention due to their potential impact on clinical decision making. Electrochemical biosensors have become one of the preferred detection approaches, due to the simplicity of the accompanying instrumentation. This chapter will explore how electrochemical sensors can be utilized for detection of multiple analytes by integration of sensors into microfluidic microsystems. Some key fabrication technologies for such devices will be presented utilizing polymer microfabrication, paper-based approaches, and the use of printed circuit boards. Next, the use of electrode arrays will be presented along with some commercial platforms, outlining plausible paths towards a successful electrochemical multiplexed sensor. Novel approaches based on microbeads and various labels will then be introduced along with various strategies and technologies utilized to achieve ultrasensitive multiplexed detection.

Original language	English
Title of host publication	Studies in Systems, Decision and Control
Editors	Gorachand Dutta, Arindam Biswas, Amian Chakrabarti
Publisher	Springer Nature
Chapter	3
Pages	63-93
Number of pages	31
ISBN (Electronic)	9789811596124
ISBN (Print)	9789811596117
DOIs	https://doi.org/10.1007/978-981-15-9612-4_3
Publication status	Published - 5 Jan 2021

Publication series

Name	Studies in Systems, Decision and Control
Volume	327
ISSN (Print)	2198-4182
ISSN (Electronic)	2198-4190

Bibliographical note

Funding Information:
The financial support through the Fundamental Research Grant Scheme (FRGS)-5540309 from Ministry of Education (Malaysia) are appreciatively acknowledged including the support from Universiti Putra Malaysia and Universiti Teknikal Malaysia Melaka. We also wish to express our very sincere thanks to the very competent reviewers for the good comments and suggestions.

Funding Information:
Acknowledgments: The financial support through the Fundamental Research Grant Scheme (FRGS)–5540309 from Ministry of Education (Malaysia) are appreciatively acknowledged including the support from Universiti Putra Malaysia and Universiti Teknikal Malaysia Melaka. We also wish to express our very sincere thanks to the very competent reviewers for the good comments and suggestions.

Publisher Copyright:
© 2021, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

Keywords

Electrochemical biosensors
Electrode arrays
Microfluidics integration
Multiplex immunoassays
Printed circuit boards

ASJC Scopus subject areas

Computer Science (miscellaneous)
Control and Systems Engineering
Automotive Engineering
Social Sciences (miscellaneous)
Economics, Econometrics and Finance (miscellaneous)
Control and Optimization
Decision Sciences (miscellaneous)

Access to Document

10.1007/978-981-15-9612-4_3

Multiplex_book_chapter_Final.PDF
This is a post-peer-review, pre-copyedit version of a chapter published in Zupancic, U, Rainbow, J, Flynn, C, Aidoo-Brown, J, Estrela, P & Moschou, D 2021, Strategies for Multiplexed Electrochemical Sensor Development. in G Dutta, A Biswas & A Chakrabarti (eds), Modern Techniques in Biosensors: Detection Methods and Commercial Aspects. Studies in Systems, Decision and Control, vol. 327, Springer Nature, pp. 63-93.. The final authenticated version is available online at: https://doi.org/10.1007/978-981-15-9612-4_3
Accepted author manuscript, 2.05 MB

Cite this

Zupancic, U., Rainbow, J., Flynn, C., Aidoo-Brown, J., Estrela, P., & Moschou, D. (2021). Strategies for Multiplexed Electrochemical Sensor Development. In G. Dutta, A. Biswas, & A. Chakrabarti (Eds.), Studies in Systems, Decision and Control (pp. 63-93). (Studies in Systems, Decision and Control; Vol. 327). Springer Nature. https://doi.org/10.1007/978-981-15-9612-4_3

Strategies for Multiplexed Electrochemical Sensor Development. / Zupancic, Uros; Rainbow, Josh; Flynn, Connor et al.
Studies in Systems, Decision and Control. ed. / Gorachand Dutta; Arindam Biswas; Amian Chakrabarti. Springer Nature, 2021. p. 63-93 (Studies in Systems, Decision and Control; Vol. 327).

Research output: Chapter or section in a book/report/conference proceeding › Chapter or section

@inbook{69d5f06742ef4b6b94b7f4bf034064fe,

title = "Strategies for Multiplexed Electrochemical Sensor Development",

abstract = "Detection of multiple biomarkers for disease diagnosis or treatment monitoring has received a lot of attention due to their potential impact on clinical decision making. Electrochemical biosensors have become one of the preferred detection approaches, due to the simplicity of the accompanying instrumentation. This chapter will explore how electrochemical sensors can be utilized for detection of multiple analytes by integration of sensors into microfluidic microsystems. Some key fabrication technologies for such devices will be presented utilizing polymer microfabrication, paper-based approaches, and the use of printed circuit boards. Next, the use of electrode arrays will be presented along with some commercial platforms, outlining plausible paths towards a successful electrochemical multiplexed sensor. Novel approaches based on microbeads and various labels will then be introduced along with various strategies and technologies utilized to achieve ultrasensitive multiplexed detection.",

keywords = "Electrochemical biosensors, Electrode arrays, Microfluidics integration, Multiplex immunoassays, Printed circuit boards",

author = "Uros Zupancic and Josh Rainbow and Connor Flynn and Josephine Aidoo-Brown and Pedro Estrela and Despina Moschou",

note = "Funding Information: The financial support through the Fundamental Research Grant Scheme (FRGS)-5540309 from Ministry of Education (Malaysia) are appreciatively acknowledged including the support from Universiti Putra Malaysia and Universiti Teknikal Malaysia Melaka. We also wish to express our very sincere thanks to the very competent reviewers for the good comments and suggestions. Funding Information: Acknowledgments: The financial support through the Fundamental Research Grant Scheme (FRGS)–5540309 from Ministry of Education (Malaysia) are appreciatively acknowledged including the support from Universiti Putra Malaysia and Universiti Teknikal Malaysia Melaka. We also wish to express our very sincere thanks to the very competent reviewers for the good comments and suggestions. Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.",

year = "2021",

month = jan,

day = "5",

doi = "10.1007/978-981-15-9612-4_3",

language = "English",

isbn = "9789811596117",

series = "Studies in Systems, Decision and Control",

publisher = "Springer Nature",

pages = "63--93",

editor = "Gorachand Dutta and Arindam Biswas and Amian Chakrabarti",

booktitle = "Studies in Systems, Decision and Control",

address = "USA United States",

}

TY - CHAP

T1 - Strategies for Multiplexed Electrochemical Sensor Development

AU - Zupancic, Uros

AU - Rainbow, Josh

AU - Flynn, Connor

AU - Aidoo-Brown, Josephine

AU - Estrela, Pedro

AU - Moschou, Despina

N1 - Funding Information: The financial support through the Fundamental Research Grant Scheme (FRGS)-5540309 from Ministry of Education (Malaysia) are appreciatively acknowledged including the support from Universiti Putra Malaysia and Universiti Teknikal Malaysia Melaka. We also wish to express our very sincere thanks to the very competent reviewers for the good comments and suggestions. Funding Information: Acknowledgments: The financial support through the Fundamental Research Grant Scheme (FRGS)–5540309 from Ministry of Education (Malaysia) are appreciatively acknowledged including the support from Universiti Putra Malaysia and Universiti Teknikal Malaysia Melaka. We also wish to express our very sincere thanks to the very competent reviewers for the good comments and suggestions. Publisher Copyright: © 2021, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

PY - 2021/1/5

Y1 - 2021/1/5

N2 - Detection of multiple biomarkers for disease diagnosis or treatment monitoring has received a lot of attention due to their potential impact on clinical decision making. Electrochemical biosensors have become one of the preferred detection approaches, due to the simplicity of the accompanying instrumentation. This chapter will explore how electrochemical sensors can be utilized for detection of multiple analytes by integration of sensors into microfluidic microsystems. Some key fabrication technologies for such devices will be presented utilizing polymer microfabrication, paper-based approaches, and the use of printed circuit boards. Next, the use of electrode arrays will be presented along with some commercial platforms, outlining plausible paths towards a successful electrochemical multiplexed sensor. Novel approaches based on microbeads and various labels will then be introduced along with various strategies and technologies utilized to achieve ultrasensitive multiplexed detection.

AB - Detection of multiple biomarkers for disease diagnosis or treatment monitoring has received a lot of attention due to their potential impact on clinical decision making. Electrochemical biosensors have become one of the preferred detection approaches, due to the simplicity of the accompanying instrumentation. This chapter will explore how electrochemical sensors can be utilized for detection of multiple analytes by integration of sensors into microfluidic microsystems. Some key fabrication technologies for such devices will be presented utilizing polymer microfabrication, paper-based approaches, and the use of printed circuit boards. Next, the use of electrode arrays will be presented along with some commercial platforms, outlining plausible paths towards a successful electrochemical multiplexed sensor. Novel approaches based on microbeads and various labels will then be introduced along with various strategies and technologies utilized to achieve ultrasensitive multiplexed detection.

KW - Electrochemical biosensors

KW - Electrode arrays

KW - Microfluidics integration

KW - Multiplex immunoassays

KW - Printed circuit boards

UR - http://www.scopus.com/inward/record.url?scp=85101019275&partnerID=8YFLogxK

U2 - 10.1007/978-981-15-9612-4_3

DO - 10.1007/978-981-15-9612-4_3

M3 - Chapter or section

SN - 9789811596117

T3 - Studies in Systems, Decision and Control

SP - 63

EP - 93

BT - Studies in Systems, Decision and Control

A2 - Dutta, Gorachand

A2 - Biswas, Arindam

A2 - Chakrabarti, Amian

PB - Springer Nature

ER -

Strategies for Multiplexed Electrochemical Sensor Development

Abstract

Publication series

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this