2 Citations (Scopus)

Abstract

Mathematical models are vital interpretive and predictive tools used to assist in the understanding of cell migration. There are typically two approaches to modelling cell migration: either micro-scale, discrete or macro-scale, continuum. The discrete approach, using agent-based models (ABMs), is typically stochastic and accounts for properties at the cell-scale. Conversely, the continuum approach, in which cell density is often modelled as a system of deterministic partial differential equations (PDEs), provides a global description of the migration at the population level.
Deterministic models have the advantage that they are generally more amenable to mathematical analysis. They can lead to significant insights for situations in which the system comprises a large number of cells, at which point simulating a stochastic ABM becomes computationally expensive. However, finding an appropriate continuum model to describe the collective behaviour of a system of individual cells can be a difficult task. Deterministic models are often specified on a phenomenological basis, which reduces their predictive power. Stochastic ABMs have advantages over their deterministic continuum counterparts. In particular, ABMs can represent individual-level behaviours (such as cell proliferation and cell-cell interaction) appropriately and are amenable to direct parameterisation using experimental data. It is essential, therefore, to establish direct connections between stochastic micro-scale behaviours and deterministic macro-scale dynamics.
In this Chapter we describe how, in some situations, these two distinct modelling approaches can be unified into a discrete-continuum equivalence framework. We carry out detailed examinations of a range of fundamental models of cell movement in one dimension. We then extend the discussion to more general models, which focus on incorporating other important factors that affect the migration of cells including cell proliferation and cell-cell interactions. We provide an overview of some of the more recent advances in this field and we point out some of the relevant questions that remain unanswered.
Original languageEnglish
Title of host publicationIntegrated Population Biology and Modeling
EditorsArni S.R. Rao, Rao, C.R. Srinivasa
PublisherElsevier
Chapter2
Pages37-91
Number of pages55
DOIs
Publication statusE-pub ahead of print - 19 Jul 2018

Publication series

NameHandbook of Statistics
PublisherElsevier
Volume39

Fingerprint

Cell Migration
Cell
Modeling
Agent-based Model
Continuum
Cell proliferation
Cell Proliferation
Deterministic Model
Macros
Migration
Stochastic Model
Cells
Collective Behavior
Parameterization
Continuum Model
Partial differential equations
Mathematical Analysis
Interaction
One Dimension
Partial differential equation

Keywords

  • Agent-based models
  • Cell migration
  • Collective behavior
  • Discrete-continuum equivalence
  • Partial differential equation

ASJC Scopus subject areas

  • Statistics and Probability
  • Modelling and Simulation
  • Applied Mathematics

Cite this

Gavagnin, E., & Yates, C. (2018). Stochastic and Deterministic Modelling of Cell Migration. In A. S. R. Rao, & R. C. R. Srinivasa (Eds.), Integrated Population Biology and Modeling (pp. 37-91). (Handbook of Statistics ; Vol. 39). Elsevier. https://doi.org/https://arxiv.org/abs/1806.06724, https://doi.org/10.1016/bs.host.2018.06.002

Stochastic and Deterministic Modelling of Cell Migration. / Gavagnin, Enrico; Yates, Christian.

Integrated Population Biology and Modeling. ed. / Arni S.R. Rao; Rao, C.R. Srinivasa. Elsevier, 2018. p. 37-91 (Handbook of Statistics ; Vol. 39).

Research output: Chapter in Book/Report/Conference proceedingChapter

Gavagnin, E & Yates, C 2018, Stochastic and Deterministic Modelling of Cell Migration. in ASR Rao & RCR Srinivasa (eds), Integrated Population Biology and Modeling. Handbook of Statistics , vol. 39, Elsevier, pp. 37-91. https://doi.org/https://arxiv.org/abs/1806.06724, https://doi.org/10.1016/bs.host.2018.06.002
Gavagnin E, Yates C. Stochastic and Deterministic Modelling of Cell Migration. In Rao ASR, Srinivasa RCR, editors, Integrated Population Biology and Modeling. Elsevier. 2018. p. 37-91. (Handbook of Statistics ). https://doi.org/https://arxiv.org/abs/1806.06724, https://doi.org/10.1016/bs.host.2018.06.002
Gavagnin, Enrico ; Yates, Christian. / Stochastic and Deterministic Modelling of Cell Migration. Integrated Population Biology and Modeling. editor / Arni S.R. Rao ; Rao, C.R. Srinivasa. Elsevier, 2018. pp. 37-91 (Handbook of Statistics ).
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