Abstract
Complex stimuli responsive systems are the basis for molecular machines and computing. A dual psuedo-enantiomer system was conceived, where the combination of two 'switch-on' asymmetric catalytic cycles could be selectively triggered to afford an enantioenriched product. Two pseudo-enantiomeric proligands were designed and synthesised for selective activation by fluoride and alkaline phosphatase. The proligands were firstly incorporated into single proligand systems, and then into a dual proligand system, where enantioselectivity of up to 98 : 2 was achieved in the reduction of prochiral ketone following external stimulation.
Original language | English |
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Pages (from-to) | 2194-2199 |
Number of pages | 6 |
Journal | Organic & Biomolecular Chemistry |
Volume | 20 |
Issue number | 11 |
Early online date | 23 Feb 2022 |
DOIs | |
Publication status | Published - 16 Mar 2022 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry