Abstract
Complex stimuli responsive systems are the basis for molecular machines and computing. A dual psuedo-enantiomer system was conceived, where the combination of two 'switch-on' asymmetric catalytic cycles could be selectively triggered to afford an enantioenriched product. Two pseudo-enantiomeric proligands were designed and synthesised for selective activation by fluoride and alkaline phosphatase. The proligands were firstly incorporated into single proligand systems, and then into a dual proligand system, where enantioselectivity of up to 98 : 2 was achieved in the reduction of prochiral ketone following external stimulation.
| Original language | English |
|---|---|
| Pages (from-to) | 2194-2199 |
| Number of pages | 6 |
| Journal | Organic & Biomolecular Chemistry |
| Volume | 20 |
| Issue number | 11 |
| Early online date | 23 Feb 2022 |
| DOIs | |
| Publication status | Published - 23 Feb 2022 |
Funding
The authors gratefully acknowledge funding from the University of Bath and EPSRC. We thank the Material and Chemical Characterisation Facility (MC) at University of Bath ( https://doi.org/10.15125/mx6j-3r54 ) for technical support and assistance in this work. 2
| Funders | Funder number |
|---|---|
| Engineering and Physical Sciences Research Council |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry