TY - JOUR
T1 - Stepwise-Enhanced Tumor Targeting of Near-Infrared Emissive Au Nanoclusters with High Quantum Yields and Long-Term Stability
AU - Zhu, Hui
AU - Zhou, Yue
AU - Wang, Yu
AU - Xu, Suying
AU - James, Tony D.
AU - Wang, Leyu
N1 - Funding Information:
The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (21725501 and 21874007), Beijing Municipal Natural Science Foundation (2212011), and the Fundamental Research Funds for the Central Universities (PT2208). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award.
PY - 2022/9/27
Y1 - 2022/9/27
N2 - We developed an in situ coordination-driven spatially confined strategy for preparing near-infrared emissive gold nanoclusters encapsulated by fluorinated polymers (AuNCs@PF, λmax = 810 nm) with good stability and high quantum yields (27.7%), far higher than those previously reported for NIR AuNCs (>800 nm). Based on the stepwise enhancements including long blood circulation-induced passive tumor targeting, fluoro-enhanced tumor permeation, and tumor microenvironment (weak acid)-induced aggregation retention in cells, these AuNCs demonstrated bright and stable NIR fluorescence imaging ability in tumors. Additionally, the AuNCs@PF were capable of fluorine magnetic resonance imaging and computed tomographic imaging. The multimodal imaging of tumor-bearing mice clearly implied the potential of AuNCs@PF in biomedical fields.
AB - We developed an in situ coordination-driven spatially confined strategy for preparing near-infrared emissive gold nanoclusters encapsulated by fluorinated polymers (AuNCs@PF, λmax = 810 nm) with good stability and high quantum yields (27.7%), far higher than those previously reported for NIR AuNCs (>800 nm). Based on the stepwise enhancements including long blood circulation-induced passive tumor targeting, fluoro-enhanced tumor permeation, and tumor microenvironment (weak acid)-induced aggregation retention in cells, these AuNCs demonstrated bright and stable NIR fluorescence imaging ability in tumors. Additionally, the AuNCs@PF were capable of fluorine magnetic resonance imaging and computed tomographic imaging. The multimodal imaging of tumor-bearing mice clearly implied the potential of AuNCs@PF in biomedical fields.
UR - http://www.scopus.com/inward/record.url?scp=85138818206&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.2c02717
DO - 10.1021/acs.analchem.2c02717
M3 - Article
AN - SCOPUS:85138818206
SN - 0003-2700
VL - 94
SP - 13189
EP - 13196
JO - Analytical Chemistry
JF - Analytical Chemistry
IS - 38
ER -