Stepwise-Enhanced Tumor Targeting of Near-Infrared Emissive Au Nanoclusters with High Quantum Yields and Long-Term Stability

Hui Zhu, Yue Zhou, Yu Wang, Suying Xu, Tony D. James, Leyu Wang

Research output: Contribution to journalArticlepeer-review

10 Citations (SciVal)

Abstract

We developed an in situ coordination-driven spatially confined strategy for preparing near-infrared emissive gold nanoclusters encapsulated by fluorinated polymers (AuNCs@PF, λmax = 810 nm) with good stability and high quantum yields (27.7%), far higher than those previously reported for NIR AuNCs (>800 nm). Based on the stepwise enhancements including long blood circulation-induced passive tumor targeting, fluoro-enhanced tumor permeation, and tumor microenvironment (weak acid)-induced aggregation retention in cells, these AuNCs demonstrated bright and stable NIR fluorescence imaging ability in tumors. Additionally, the AuNCs@PF were capable of fluorine magnetic resonance imaging and computed tomographic imaging. The multimodal imaging of tumor-bearing mice clearly implied the potential of AuNCs@PF in biomedical fields.

Original languageEnglish
Pages (from-to)13189-13196
Number of pages8
JournalAnalytical Chemistry
Volume94
Issue number38
Early online date25 Sept 2022
DOIs
Publication statusPublished - 27 Sept 2022

Bibliographical note

Funding Information:
The authors gratefully acknowledge the financial support from the National Natural Science Foundation of China (21725501 and 21874007), Beijing Municipal Natural Science Foundation (2212011), and the Fundamental Research Funds for the Central Universities (PT2208). T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award.

ASJC Scopus subject areas

  • Analytical Chemistry

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