Stepwise-Enhanced Tumor Targeting of Near-Infrared Emissive Au Nanoclusters with High Quantum Yields and Long-Term Stability

Hui Zhu, Yue Zhou, Yu Wang, Suying Xu, Tony D. James, Leyu Wang

Research output: Contribution to journalArticlepeer-review

Abstract

We developed an in situ coordination-driven spatially confined strategy for preparing near-infrared emissive gold nanoclusters encapsulated by fluorinated polymers (AuNCs@PF, λmax = 810 nm) with good stability and high quantum yields (27.7%), far higher than those previously reported for NIR AuNCs (>800 nm). Based on the stepwise enhancements including long blood circulation-induced passive tumor targeting, fluoro-enhanced tumor permeation, and tumor microenvironment (weak acid)-induced aggregation retention in cells, these AuNCs demonstrated bright and stable NIR fluorescence imaging ability in tumors. Additionally, the AuNCs@PF were capable of fluorine magnetic resonance imaging and computed tomographic imaging. The multimodal imaging of tumor-bearing mice clearly implied the potential of AuNCs@PF in biomedical fields.

Original languageEnglish
Pages (from-to)13189-13196
Number of pages8
JournalAnalytical Chemistry
Volume94
Issue number38
Early online date25 Sep 2022
DOIs
Publication statusPublished - 27 Sep 2022

ASJC Scopus subject areas

  • Analytical Chemistry

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