Abstract
We report hybrid gels based on a high-amylose starch and microcrystalline cellulose with demonstrated properties for gastric-floating drug delivery purposes. The starch/cellulose gels were prepared by ionic liquid dissolution and regeneration, resulting in a continuous surface and a porous interior and a type-II crystalline structure of cellulose. These polysaccharide gels displayed satisfactory elasticity (0.88), recovery (0.26–0.36) and equilibrium swelling (1013–1369%). The hybrid gels were loaded with ranitidine hydrochloride as a model drug and subsequently, low-density starch/cellulose tablets were fabricated by vacuum-freeze-drying. In vitro tests in a simulated gastric fluid indicate that the 3:7 (wt./wt.) starch/cellulose system could maintain the buoyancy for up to 24 h with a release of 45.87% for the first 1 h and a sustained release for up to 10 h. Therefore, our results have demonstrated the excellent gastric-floating ability and sustainable drug release behavior of the starch/cellulose hybrid gels.
Original language | English |
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Pages (from-to) | 151-159 |
Number of pages | 9 |
Journal | Carbohydrate Polymers |
Volume | 215 |
DOIs | |
Publication status | Published - 1 Jul 2019 |
Funding
The authors from China would like to acknowledge the research funds from the National Natural Science Foundation of China (NSFC) –Guangdong Joint Fund under a Key Project (No. U1501214 ), National Natural Science Foundation of China (NSFC) under a General Project (No. 31871751 ), and the Guangdong Provincial Government under a YangFan Innovative and Entrepreneurial Research Team Project ( 2014YT02S029 ). F. Xie acknowledges the support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 798225 .
Funders | Funder number |
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H2020 Marie Skłodowska-Curie Actions | 798225 |
YangFan Innovative and Entrepreneurial Research Team Project | 2014YT02S029 |
Horizon 2020 Framework Programme | |
National Natural Science Foundation of China | 31871751, U1501214 |
Government of Guangdong Province |
Keywords
- Gastric-floating drug delivery system
- Gels
- Ionic liquids
- Natural polymers
- Polysaccharides
- Starch/microcrystalline cellulose hybrid materials
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry