Starch/microcrystalline cellulose hybrid gels as gastric-floating drug delivery systems

Jinchuan Xu; Xiaoyan Tan; Ling Chen; Xiaoxi Li; Fengwei Xie

doi:10.1016/j.carbpol.2019.03.078

Starch/microcrystalline cellulose hybrid gels as gastric-floating drug delivery systems

Jinchuan Xu, Xiaoyan Tan, Ling Chen, Xiaoxi Li, Fengwei Xie

Research output: Contribution to journal › Article › peer-review

49 Citations (SciVal)

Abstract

We report hybrid gels based on a high-amylose starch and microcrystalline cellulose with demonstrated properties for gastric-floating drug delivery purposes. The starch/cellulose gels were prepared by ionic liquid dissolution and regeneration, resulting in a continuous surface and a porous interior and a type-II crystalline structure of cellulose. These polysaccharide gels displayed satisfactory elasticity (0.88), recovery (0.26–0.36) and equilibrium swelling (1013–1369%). The hybrid gels were loaded with ranitidine hydrochloride as a model drug and subsequently, low-density starch/cellulose tablets were fabricated by vacuum-freeze-drying. In vitro tests in a simulated gastric fluid indicate that the 3:7 (wt./wt.) starch/cellulose system could maintain the buoyancy for up to 24 h with a release of 45.87% for the first 1 h and a sustained release for up to 10 h. Therefore, our results have demonstrated the excellent gastric-floating ability and sustainable drug release behavior of the starch/cellulose hybrid gels.

Original language	English
Pages (from-to)	151-159
Number of pages	9
Journal	Carbohydrate Polymers
Volume	215
DOIs	https://doi.org/10.1016/j.carbpol.2019.03.078
Publication status	Published - 1 Jul 2019

Funding

The authors from China would like to acknowledge the research funds from the National Natural Science Foundation of China (NSFC) –Guangdong Joint Fund under a Key Project (No. U1501214 ), National Natural Science Foundation of China (NSFC) under a General Project (No. 31871751 ), and the Guangdong Provincial Government under a YangFan Innovative and Entrepreneurial Research Team Project ( 2014YT02S029 ). F. Xie acknowledges the support from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 798225 .

Funders	Funder number
H2020 Marie Skłodowska-Curie Actions	798225
YangFan Innovative and Entrepreneurial Research Team Project	2014YT02S029
Horizon 2020 Framework Programme
National Natural Science Foundation of China	31871751, U1501214
Government of Guangdong Province

Keywords

Gastric-floating drug delivery system
Gels
Ionic liquids
Natural polymers
Polysaccharides
Starch/microcrystalline cellulose hybrid materials

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

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10.1016/j.carbpol.2019.03.078

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title = "Starch/microcrystalline cellulose hybrid gels as gastric-floating drug delivery systems",

abstract = "We report hybrid gels based on a high-amylose starch and microcrystalline cellulose with demonstrated properties for gastric-floating drug delivery purposes. The starch/cellulose gels were prepared by ionic liquid dissolution and regeneration, resulting in a continuous surface and a porous interior and a type-II crystalline structure of cellulose. These polysaccharide gels displayed satisfactory elasticity (0.88), recovery (0.26–0.36) and equilibrium swelling (1013–1369%). The hybrid gels were loaded with ranitidine hydrochloride as a model drug and subsequently, low-density starch/cellulose tablets were fabricated by vacuum-freeze-drying. In vitro tests in a simulated gastric fluid indicate that the 3:7 (wt./wt.) starch/cellulose system could maintain the buoyancy for up to 24 h with a release of 45.87% for the first 1 h and a sustained release for up to 10 h. Therefore, our results have demonstrated the excellent gastric-floating ability and sustainable drug release behavior of the starch/cellulose hybrid gels.",

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author = "Jinchuan Xu and Xiaoyan Tan and Ling Chen and Xiaoxi Li and Fengwei Xie",

year = "2019",

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doi = "10.1016/j.carbpol.2019.03.078",

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AU - Xu, Jinchuan

AU - Tan, Xiaoyan

AU - Chen, Ling

AU - Li, Xiaoxi

AU - Xie, Fengwei

PY - 2019/7/1

Y1 - 2019/7/1

N2 - We report hybrid gels based on a high-amylose starch and microcrystalline cellulose with demonstrated properties for gastric-floating drug delivery purposes. The starch/cellulose gels were prepared by ionic liquid dissolution and regeneration, resulting in a continuous surface and a porous interior and a type-II crystalline structure of cellulose. These polysaccharide gels displayed satisfactory elasticity (0.88), recovery (0.26–0.36) and equilibrium swelling (1013–1369%). The hybrid gels were loaded with ranitidine hydrochloride as a model drug and subsequently, low-density starch/cellulose tablets were fabricated by vacuum-freeze-drying. In vitro tests in a simulated gastric fluid indicate that the 3:7 (wt./wt.) starch/cellulose system could maintain the buoyancy for up to 24 h with a release of 45.87% for the first 1 h and a sustained release for up to 10 h. Therefore, our results have demonstrated the excellent gastric-floating ability and sustainable drug release behavior of the starch/cellulose hybrid gels.

AB - We report hybrid gels based on a high-amylose starch and microcrystalline cellulose with demonstrated properties for gastric-floating drug delivery purposes. The starch/cellulose gels were prepared by ionic liquid dissolution and regeneration, resulting in a continuous surface and a porous interior and a type-II crystalline structure of cellulose. These polysaccharide gels displayed satisfactory elasticity (0.88), recovery (0.26–0.36) and equilibrium swelling (1013–1369%). The hybrid gels were loaded with ranitidine hydrochloride as a model drug and subsequently, low-density starch/cellulose tablets were fabricated by vacuum-freeze-drying. In vitro tests in a simulated gastric fluid indicate that the 3:7 (wt./wt.) starch/cellulose system could maintain the buoyancy for up to 24 h with a release of 45.87% for the first 1 h and a sustained release for up to 10 h. Therefore, our results have demonstrated the excellent gastric-floating ability and sustainable drug release behavior of the starch/cellulose hybrid gels.

KW - Gastric-floating drug delivery system

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KW - Natural polymers

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Starch/microcrystalline cellulose hybrid gels as gastric-floating drug delivery systems

Abstract

Funding

Keywords

ASJC Scopus subject areas

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