Abstract
The aim of this study was to prepare and characterize a novel type of starch-coated microparticles (MPs) allowing site-specific delivery of bioactives to the colon. An oral colon-specific controlled-release system was developed in the form of MPs coated with a resistant starch (RS2/RS3) film (RS@MPs) through an aqueous suspension coating process. The RS2 was chosen from a high-amylose cornstarch with 88.5% digestion resistibility. The RS3 was prepared by a high-temperature/pressure (HTP) treatment, with the following of enzymatic debranching, and retrogradation, resulting in a dramatic increase in enzymatic resistance (RS3 content: 76.6%). RS@MPs showed 40.7% of 5-aminosalicylic acid release within 8 h. The in vivo study of fluorescein-loaded RS@MPs indicated the high acidic and enzymatic resistibility of RS@MPs and a restrained release in the upper GIT. Therefore, RS@MPs has revealed to be a high potential system for accurately targeting bioactive compound delivery to the colon.
| Original language | English |
|---|---|
| Pages (from-to) | 242-254 |
| Number of pages | 13 |
| Journal | Carbohydrate Polymers |
| Volume | 191 |
| DOIs | |
| Publication status | Published - 1 Jul 2018 |
Funding
This research has been financially supported by the National Natural Science Foundation of China (NSFC)–Guangdong Joint Foundation Key Project ( U1501214 ), and YangFan Innovative and Entrepreneurial Research Team Project ( 2014YT02S029 ). J. Chen also would like to thank the Guangzhou Elite Project (GEP) for providing research funding for her visiting studies at The University of Queensland (UQ) as part of her PhD work.
Keywords
- Aqueous suspension film coating
- Controlled release
- Oral colon-specific delivery
- Resistant starch
ASJC Scopus subject areas
- Organic Chemistry
- Polymers and Plastics
- Materials Chemistry