Staphylococcus epidermidis in biomaterial-associated infections

Dietrich Mack, Angharad P. Davies, Llinos G. Harris, Rose Jeeves, Ben Pascoe, Johannes K M Knobloch, Holger Rohde, Thomas S. Wilkinson

Research output: Chapter in Book/Report/Conference proceedingChapter

24 Citations (Scopus)

Abstract

Coagulase-negative staphylococci, mainly Staphylococcus epidermidis, are currently the most frequent cause of hospital acquired infections in the USA. Mostly, but not exclusively, S. epidermidis infections are linked to the use of implanted medical devices like central venous catheters, prosthetic joints and heart valves, pacemakers, cardiac assist devices, cerebrospinal fluid shunts, and intraocular lenses. As new molecular techniques reveal that S. epidermidis are by no means the most prominent bacteria of the skin and mucous membrane flora, the implication is that S. epidermidis has specific virulence factors, which transforms this commensal bacterial species into one of the most successful pathogens in modern medicine. A vast array of specific attachment factors for native and host protein-modified device surfaces and the ability to accumulate in adherent multilayered biofilms appear to be vital for the success of S. epidermidis as a pathogen. Biofilm formation contributes to the ability of the organism to withstand the host's innate and acquired immune defense mechanisms and to resist antimicrobial therapy, so that device removal is a regular feature for the treatment of S. epidermidis biomaterial-associated infection. Recent developments in the understanding of S. epidermidis virulence are reviewed in this chapter.

Original languageEnglish
Title of host publicationBiomaterials Associated Infection
Subtitle of host publicationImmunological Aspects and Antimicrobial Strategies
EditorsF. Moriarty, S. A. J. Zaat
Place of PublicationNew York, U. S. A.
PublisherSpringer New York
Pages25-56
Number of pages32
ISBN (Print)9781461410300
DOIs
Publication statusPublished - 1 Nov 2013

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Staphylococcus epidermidis
Biocompatible Materials
Infection
Biofilms
Equipment and Supplies
Integration Host Factors
Cerebrospinal Fluid Shunts
Device Removal
Modern 1601-history
Central Venous Catheters
Coagulase
Intraocular Lenses
Heart Valves
Virulence Factors
Cross Infection
Staphylococcus
Virulence
Mucous Membrane
Joints
Bacteria

Cite this

Mack, D., Davies, A. P., Harris, L. G., Jeeves, R., Pascoe, B., Knobloch, J. K. M., ... Wilkinson, T. S. (2013). Staphylococcus epidermidis in biomaterial-associated infections. In F. Moriarty, & S. A. J. Zaat (Eds.), Biomaterials Associated Infection: Immunological Aspects and Antimicrobial Strategies (pp. 25-56). New York, U. S. A.: Springer New York. https://doi.org/10.1007/978-1-4614-1031-7_2

Staphylococcus epidermidis in biomaterial-associated infections. / Mack, Dietrich; Davies, Angharad P.; Harris, Llinos G.; Jeeves, Rose; Pascoe, Ben; Knobloch, Johannes K M; Rohde, Holger; Wilkinson, Thomas S.

Biomaterials Associated Infection: Immunological Aspects and Antimicrobial Strategies. ed. / F. Moriarty; S. A. J. Zaat. New York, U. S. A. : Springer New York, 2013. p. 25-56.

Research output: Chapter in Book/Report/Conference proceedingChapter

Mack, D, Davies, AP, Harris, LG, Jeeves, R, Pascoe, B, Knobloch, JKM, Rohde, H & Wilkinson, TS 2013, Staphylococcus epidermidis in biomaterial-associated infections. in F Moriarty & SAJ Zaat (eds), Biomaterials Associated Infection: Immunological Aspects and Antimicrobial Strategies. Springer New York, New York, U. S. A., pp. 25-56. https://doi.org/10.1007/978-1-4614-1031-7_2
Mack D, Davies AP, Harris LG, Jeeves R, Pascoe B, Knobloch JKM et al. Staphylococcus epidermidis in biomaterial-associated infections. In Moriarty F, Zaat SAJ, editors, Biomaterials Associated Infection: Immunological Aspects and Antimicrobial Strategies. New York, U. S. A.: Springer New York. 2013. p. 25-56 https://doi.org/10.1007/978-1-4614-1031-7_2
Mack, Dietrich ; Davies, Angharad P. ; Harris, Llinos G. ; Jeeves, Rose ; Pascoe, Ben ; Knobloch, Johannes K M ; Rohde, Holger ; Wilkinson, Thomas S. / Staphylococcus epidermidis in biomaterial-associated infections. Biomaterials Associated Infection: Immunological Aspects and Antimicrobial Strategies. editor / F. Moriarty ; S. A. J. Zaat. New York, U. S. A. : Springer New York, 2013. pp. 25-56
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