Standardised cannabis metrics: Opportunities for tracking how cannabis use affects neurodevelopmental trajectories in youth cohorts worldwide

Valentina Lorenzetti, Tom P. Freeman

Research output: Contribution to journalComment/debatepeer-review

Original languageEnglish
Article numbere13309
JournalAddiction Biology
Volume28
Issue number8
Early online date6 Jul 2023
DOIs
Publication statusPublished - 31 Aug 2023

Bibliographical note

Funding Information:
The (5 mg of THC) has been endorsed by NIDA, NIMH and major health organisations (NOT‐DA‐21‐049). As such, it is now a recommended reporting requirement for all investigators funded by these funding organisations. This will ultimately increase methodological consistency and quality of evidence in research investigating the possible harms and benefits of cannabis use. Because the applies to all cannabis products and methods of administration, integration of this tool into developmental cohort studies holds promise for measuring youth cannabis use and its consequences. Of relevance for neuromaturation and youth health, THC drives cannabis' psychoactive, addictive, psychotogenic and anxiogenic properties and directly affects the endocannabinoid system that regulates youth neuromaturation, via directly binding to brain cannabinoid receptors type 1. Standard THC Unit 7 Standard THC Unit 8 9 10 11 12 13

Funding Information:
VL is supported by an Al and Val Rosenstrauss Research Fellowship (2022–2026), by a National Health Medical and Research Council Investigator Fellowship (2023–2027, NHMRC ID: 2016833) and by an Australian Catholic University competitive scheme. Open access publishing facilitated by Australian Catholic University, as part of the Wiley - Australian Catholic University agreement via the Council of Australian University Librarians.

Funding

The (5 mg of THC) has been endorsed by NIDA, NIMH and major health organisations (NOT‐DA‐21‐049). As such, it is now a recommended reporting requirement for all investigators funded by these funding organisations. This will ultimately increase methodological consistency and quality of evidence in research investigating the possible harms and benefits of cannabis use. Because the applies to all cannabis products and methods of administration, integration of this tool into developmental cohort studies holds promise for measuring youth cannabis use and its consequences. Of relevance for neuromaturation and youth health, THC drives cannabis' psychoactive, addictive, psychotogenic and anxiogenic properties and directly affects the endocannabinoid system that regulates youth neuromaturation, via directly binding to brain cannabinoid receptors type 1. Standard THC Unit 7 Standard THC Unit 8 9 10 11 12 13 VL is supported by an Al and Val Rosenstrauss Research Fellowship (2022–2026), by a National Health Medical and Research Council Investigator Fellowship (2023–2027, NHMRC ID: 2016833) and by an Australian Catholic University competitive scheme. Open access publishing facilitated by Australian Catholic University, as part of the Wiley - Australian Catholic University agreement via the Council of Australian University Librarians.

Keywords

  • cannabis
  • cohort
  • iCannToolkit
  • international cannabis toolkit
  • standard unit
  • standardised metrics
  • THC
  • youth

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Pharmacology
  • Psychiatry and Mental health

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