Spin diffusion transfer difference (SDTD) NMR: An advanced method for the characterisation of water structuration within particle networks

Valeria Gabrielli, Agne Kuraite, Marcelo Alves da Silva, Karen J. Edler, Jesús Angulo, Ridvan Nepravishta, Juan C. Muñoz–García, Yaroslav Z. Khimyak

Research output: Contribution to journalArticlepeer-review

7 Citations (SciVal)
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Hypothesis: The classical STD NMR protocol to monitor solvent interactions in gels is strongly dependent on gelator and solvent concentrations and does not report on the degree of structuration of the solvent at the particle/solvent interface. We hypothesised that, for suspensions of large gelator particles, solvent structuration could be characterised by STD NMR when taking into account the particle-to-solvent 1H–1H spin diffusion transfer using the 1D diffusion equation. Experiments: We have carried out a systematic study on effect of gelator and solvent concentrations, and gelator surface charge, affecting the behaviour of the classical STD NMR build-up curves. To do so, we have characterised solvent interactions in dispersions of starch and cellulose-like particles prepared in deuterated water and alcohol/D2O mixtures. Findings: The Spin Diffusion Transfer Difference (SDTD) NMR protocol is independent of the gelator and solvent concentrations, hence allowing the estimation of the degree of solvent structuration within different particle networks. In addition, the simulation of SDTD build-up curves using the general one–dimensional diffusion equation allows the determination of minimum distances (r) and spin diffusion rates (D) at the particle/solvent interface. This novel NMR protocol can be readily extended to characterise the solvent(s) organisation in any type of colloidal systems constituted by large particles.

Original languageEnglish
Pages (from-to)217-227
Number of pages11
JournalJournal of Colloid and Interface Science
Early online date9 Mar 2021
Publication statusPublished - 15 Jul 2021

Bibliographical note

Funding Information:
We thank the GelEnz consortium, which is funded by EPSRC (Grant Research Number: IUK 59000 442149). The Engineering and Physical Sciences Research Council (EPSRC) is acknowledged for provision of financial support (EP/N033337/1) for J.C.M.G. J.A. and Y.Z.K. and (EP/N033310/1) for M.A.d.S and K.J.E. R.N acknowledges financial support from BBSRC (grant BB/P010660/1). We are also grateful for UEA Faculty of Science NMR facility. V.G. would like to acknowledge the support of BBSRC Norwich Research Park Bioscience Doctoral Training Grant (BB/M011216/1). Additional research data supporting this publication are available as electronic supplementary files at the following link:https://pure.uea.ac.uk/admin/editor/dk/atira/pure/modules/datasets/external/model/dataset/editor/dataseteditor.xhtml?id=186320920


  • Hydrogel
  • Saturation transfer difference NMR
  • Solvation properties
  • Spin diffusion

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Surfaces, Coatings and Films
  • Colloid and Surface Chemistry


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