SMARTPHONE MULTIPLEX MICROCAPILLARY DIAGNOSTICS USING CYGNUS: AN EVALUATION OF RAPID SEROTYPE-SPECIFIC DENGUE NS1 DETECTION USING 255 PATIENT SAMPLES

Sarah Needs, Sirintra Sirivisoot, Sophie Jegouic, Tanapan Prommool, Nuno Reis, Prasit Lu-Angaram, Chatchawan Srisawat, Prida Malasit, Panisadee Avirutnan, Chunya Puttikhunt, Alexander Edwards

Research output: Chapter or section in a book/report/conference proceedingChapter in a published conference proceeding

Abstract

Rapid NS1 tests help dengue diagnosis but cannot identify serotype. A simple,economical, point-of-caredevice for serotyping is still required. We present a gravity driven, smartphone compatible, microfluidic device using microcapillary film (MCF) to perform multiplex serotype-specific detection of dengue virus NS1. A novel device - termed Cygnus - with a stackable design allows analysis of 1 to 12 samples in parallel in 30 minutes using undiluted patient plasma.

Original languageEnglish
Title of host publicationMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages773-774
Number of pages2
ISBN (Electronic)9781733419031
Publication statusPublished - 14 Oct 2021
Event25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 - Palm Springs, Virtual, USA United States
Duration: 10 Oct 202114 Oct 2021

Publication series

NameMicroTAS 2021 - 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021
Country/TerritoryUSA United States
CityPalm Springs, Virtual
Period10/10/2114/10/21

Bibliographical note

Funding Information:
This study was funded by grants from the Newton Fund (British Council Institutional Links IL35237556) and the Wellcome Trust (Pathfinder Award 204388/Z/16/Z). The clinical cohorts were supported by the Office of the Higher Education Commission, Mahidol University under the National Research Universities Initiative and Research Chair Grant, NSTDA, Thailand. Dumrong Mairiang and Nattaya Tangthawornchaikul (National Science and Technology Development Agency), Adisak Songjaeng, Arunee Mapralub, Supansa Pakdee, Chotika Kaewpuenk, Dararat Prayongkul and Oranicha Khamprapa (Faculty of Medicine Siriraj Hospital, Mahidol University) contributed to dengue hospital cohorts where the collection of dengue clinical specimens and database were used in this study.

Keywords

  • dengue
  • diagnostic
  • fluorescence
  • infectious disease
  • smartphone

ASJC Scopus subject areas

  • Bioengineering
  • Chemical Engineering (miscellaneous)

Fingerprint

Dive into the research topics of 'SMARTPHONE MULTIPLEX MICROCAPILLARY DIAGNOSTICS USING CYGNUS: AN EVALUATION OF RAPID SEROTYPE-SPECIFIC DENGUE NS1 DETECTION USING 255 PATIENT SAMPLES'. Together they form a unique fingerprint.

Cite this