Small scale assays for studying dissolution of pharmaceutical cocrystals for oral administration

Karl J. Box, John Comer, Robert Taylor, Shyam Karki, Rebeca Ruiz, Robert Price, Nikoletta Fotaki

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)
175 Downloads (Pure)

Abstract

The purpose of this study was to better understand the dissolution properties and precipitation behavior of pharmaceutical cocrystals of poorly soluble drugs for the potential for oral administration based on a small-scale dissolution assay. Carbamazepine and indomethacin cocrystals with saccharin and nicotinamide as coformers were prepared with the sonic slurry method. Dissolution of the poorly soluble drugs indomethacin and carbamazepine and their cocrystals was studied with a small-scale dissolution assay installed on a SiriusT3 instrument. Two methodologies were used: (i) surface dissolution of pressed tablet (3 mm) in 20 mL running for fixed times at four pH stages (pH 1.8, pH 3.9, pH 5.4, pH 7.3) and (ii) powder dissolution (2.6 mg) in 2 mL at a constant pH (pH 2). Improved dissolution and useful insights into precipitation kinetics of poorly soluble compounds from the cocrystal form can be revealed by the small-scale dissolution assay. A clear difference in dissolution/precipitation behaviour can be observed based on the characteristics of the coformer used.
Original languageEnglish
Pages (from-to)245-251
JournalAAPS PharmSciTech
Volume17
Issue number2
Early online date25 Jul 2015
DOIs
Publication statusPublished - Apr 2016

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