Small-molecule fluorescence-based probes for interrogating major organ diseases

Hai Hao Han; He Tian; Yi Zang; Adam C. Sedgwick; Jia Li; Jonathan L. Sessler; Xiao Peng He; Tony D. James; Xiao Peng He

doi:10.1039/d0cs01183e

Small-molecule fluorescence-based probes for interrogating major organ diseases

Hai Hao Han, He Tian, Yi Zang, Adam C. Sedgwick, Jia Li, Jonathan L. Sessler, Xiao Peng He, Tony D. James, Xiao Peng He

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

196 Citations (SciVal)

Abstract

Chemical tools that allow the real-time monitoring of organ function and the visualisation of organ-related processes at the cellular level are of great importance in biological research. The upregulation/downregulation of specific biomarkers is often associated with the development of organ related diseases. Small-molecule fluorescent probes have the potential to create advances in our understanding of these disorders. Viable probes should be endowed with a number of key features that include high biomarker sensitivity, low limit of detection, fast response times and appropriate in vitro and in vivo biocompatibility. In this tutorial review, we discuss the development of probes that allow the targeting of organ related processes in vitro and in vivo. We highlight the design strategy that underlies the preparation of various promising probes, their optical response to key biomarkers, and proof-of-concept biological studies. The inherent drawbacks and limitations are discussed as are the current challenges and opportunities in the field. The hope is that this tutorial review will inspire the further development of small-molecule fluorescent probes that could aid the study of pathogenic conditions that contribute to organ-related diseases. This journal is

Original language	English
Pages (from-to)	9391-9429
Number of pages	39
Journal	Chemical Society Reviews
Volume	50
Issue number	17
Early online date	7 Jul 2021
DOIs	https://doi.org/10.1039/d0cs01183e
Publication status	Published - 7 Sept 2021

Bibliographical note

Funding Information:
X.-P. H. thanks the National Natural Science Foundation of China (No. 21788102, 91853201), the National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (No. 17520750100), the Fundamental Research Funds for the Central Universities (222201717003) and the Programme of Introducing Talents of Discipline to Universities (B16017) for financial support. H.-H. H. would like to thank the Project funded by China Postdoctoral Science Foundation (No. 2020M681196). T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). Support from the Robert A. Welch Foundation (F-0018 to J. L. S.) is also gratefully acknowledged.

ASJC Scopus subject areas

General Chemistry

Access to Document

10.1039/d0cs01183eLicence: CC BY

Cite this

@article{86069405f50a41c2b3df6bb5c773ec9a,

title = "Small-molecule fluorescence-based probes for interrogating major organ diseases",

abstract = "Chemical tools that allow the real-time monitoring of organ function and the visualisation of organ-related processes at the cellular level are of great importance in biological research. The upregulation/downregulation of specific biomarkers is often associated with the development of organ related diseases. Small-molecule fluorescent probes have the potential to create advances in our understanding of these disorders. Viable probes should be endowed with a number of key features that include high biomarker sensitivity, low limit of detection, fast response times and appropriate in vitro and in vivo biocompatibility. In this tutorial review, we discuss the development of probes that allow the targeting of organ related processes in vitro and in vivo. We highlight the design strategy that underlies the preparation of various promising probes, their optical response to key biomarkers, and proof-of-concept biological studies. The inherent drawbacks and limitations are discussed as are the current challenges and opportunities in the field. The hope is that this tutorial review will inspire the further development of small-molecule fluorescent probes that could aid the study of pathogenic conditions that contribute to organ-related diseases. This journal is ",

author = "Han, {Hai Hao} and He Tian and Yi Zang and Sedgwick, {Adam C.} and Jia Li and Sessler, {Jonathan L.} and He, {Xiao Peng} and James, {Tony D.} and He, {Xiao Peng}",

note = "Funding Information: X.-P. H. thanks the National Natural Science Foundation of China (No. 21788102, 91853201), the National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (No. 17520750100), the Fundamental Research Funds for the Central Universities (222201717003) and the Programme of Introducing Talents of Discipline to Universities (B16017) for financial support. H.-H. H. would like to thank the Project funded by China Postdoctoral Science Foundation (No. 2020M681196). T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). Support from the Robert A. Welch Foundation (F-0018 to J. L. S.) is also gratefully acknowledged. ",

year = "2021",

month = sep,

day = "7",

doi = "10.1039/d0cs01183e",

language = "English",

volume = "50",

pages = "9391--9429",

journal = "Chemical Society Reviews",

issn = "0306-0012",

publisher = "Royal Society of Chemistry",

number = "17",

}

TY - JOUR

T1 - Small-molecule fluorescence-based probes for interrogating major organ diseases

AU - Han, Hai Hao

AU - Tian, He

AU - Zang, Yi

AU - Sedgwick, Adam C.

AU - Li, Jia

AU - Sessler, Jonathan L.

AU - He, Xiao Peng

AU - James, Tony D.

AU - He, Xiao Peng

N1 - Funding Information: X.-P. H. thanks the National Natural Science Foundation of China (No. 21788102, 91853201), the National Key Sci-Tech Special Projects of Infection Diseases of China (2018ZX10732202), the Shanghai Municipal Science and Technology Major Project (No. 2018SHZDZX03), the International Cooperation Program of Shanghai Science and Technology Committee (No. 17520750100), the Fundamental Research Funds for the Central Universities (222201717003) and the Programme of Introducing Talents of Discipline to Universities (B16017) for financial support. H.-H. H. would like to thank the Project funded by China Postdoctoral Science Foundation (No. 2020M681196). T. D. J. wishes to thank the Royal Society for a Wolfson Research Merit Award and the Open Research Fund of the School of Chemistry and Chemical Engineering, Henan Normal University for support (2020ZD01). Support from the Robert A. Welch Foundation (F-0018 to J. L. S.) is also gratefully acknowledged.

PY - 2021/9/7

Y1 - 2021/9/7

N2 - Chemical tools that allow the real-time monitoring of organ function and the visualisation of organ-related processes at the cellular level are of great importance in biological research. The upregulation/downregulation of specific biomarkers is often associated with the development of organ related diseases. Small-molecule fluorescent probes have the potential to create advances in our understanding of these disorders. Viable probes should be endowed with a number of key features that include high biomarker sensitivity, low limit of detection, fast response times and appropriate in vitro and in vivo biocompatibility. In this tutorial review, we discuss the development of probes that allow the targeting of organ related processes in vitro and in vivo. We highlight the design strategy that underlies the preparation of various promising probes, their optical response to key biomarkers, and proof-of-concept biological studies. The inherent drawbacks and limitations are discussed as are the current challenges and opportunities in the field. The hope is that this tutorial review will inspire the further development of small-molecule fluorescent probes that could aid the study of pathogenic conditions that contribute to organ-related diseases. This journal is

AB - Chemical tools that allow the real-time monitoring of organ function and the visualisation of organ-related processes at the cellular level are of great importance in biological research. The upregulation/downregulation of specific biomarkers is often associated with the development of organ related diseases. Small-molecule fluorescent probes have the potential to create advances in our understanding of these disorders. Viable probes should be endowed with a number of key features that include high biomarker sensitivity, low limit of detection, fast response times and appropriate in vitro and in vivo biocompatibility. In this tutorial review, we discuss the development of probes that allow the targeting of organ related processes in vitro and in vivo. We highlight the design strategy that underlies the preparation of various promising probes, their optical response to key biomarkers, and proof-of-concept biological studies. The inherent drawbacks and limitations are discussed as are the current challenges and opportunities in the field. The hope is that this tutorial review will inspire the further development of small-molecule fluorescent probes that could aid the study of pathogenic conditions that contribute to organ-related diseases. This journal is

UR - http://www.scopus.com/inward/record.url?scp=85114325339&partnerID=8YFLogxK

U2 - 10.1039/d0cs01183e

DO - 10.1039/d0cs01183e

M3 - Review article

AN - SCOPUS:85114325339

SN - 0306-0012

VL - 50

SP - 9391

EP - 9429

JO - Chemical Society Reviews

JF - Chemical Society Reviews

IS - 17

ER -

Small-molecule fluorescence-based probes for interrogating major organ diseases

Abstract

Bibliographical note

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this