Skin-'that unfakeable young surface'

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Abstract

The 20-to 25-year period from the mid-1960s to the early 1990s represents, in many ways, a 'golden era' in the understanding of skin barrier function, percutaneous penetration and (trans)dermal drug delivery. From the ground-breaking mechanistic work of Scheuplein and Blank, and the 'gold standard' in vivo skin absorption experiments of Feldmann and Maibach, through the unravelling of the stratum corneum's structural and physicochemical characteristics that make it such an incredible feat of bioengineering, to the elegant biophysical and modelling studies of Potts, Francoeur and many others, the idea of administering drugs rationally to treat both local and systemic diseases was transformed from something close to the ravings of a lunatic to the reality of significant therapeutic and commercial success. This short article attempts to pick out some of the highlights along the way from the viewpoint of an interested observer and occasional participant in the 'action'.

Original languageEnglish
Pages (from-to)181-189
Number of pages9
JournalSkin Pharmacology and Physiology
Volume26
Issue number4-6
DOIs
Publication statusPublished - 31 Jul 2013

Keywords

  • Predicting percutaneous absorption
  • Skin barrier function
  • Skin penetration
  • Stratum corneum
  • Stratum corneum intercellular lipids

ASJC Scopus subject areas

  • Physiology
  • Pharmacology
  • Dermatology

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