Abstract
Cardiac biomarkers have an essential role in diagnosis, risk stratification, clinical and treatment decisions for patients presenting symptoms of e.g. Myocardial Infarction (MI) and Pulmonary Embolism (PE). This paper shows for the first time simultaneous cheap-optical, colourimetric quantitation of cardiac Troponin I (TnI), BNP and D-dimer in whole blood using fluoropolymer microfluidic strips, with a limit of detection (LoD) of 71, 439 and 55 pg/ml, respectively, which compares well with the cut-off values reported for existent commercial-singleplex point-of-care cardiac tests with the advantage of quantitation of multiple biomarkers.
| Original language | English |
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| Title of host publication | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 |
| Publisher | Chemical and Biological Microsystems Society |
| Pages | 1588-1589 |
| Number of pages | 2 |
| ISBN (Electronic) | 9781733419000 |
| Publication status | Published - 27 Oct 2019 |
| Event | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 - Basel, Switzerland Duration: 27 Oct 2019 → 31 Oct 2019 |
Publication series
| Name | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 |
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Conference
| Conference | 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 |
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| Country/Territory | Switzerland |
| City | Basel |
| Period | 27/10/19 → 31/10/19 |
Funding
The authors are grateful to Patrick Hester from Lamina Dielectrics Ltd (Billingshurst, West Sussex, UK) for supplying the FEP MCF material and SBRI Healthcare/Innovate UK for funding this research.
Keywords
- BNP
- Cardiac biomarkers
- D-dimer
- Fluoropolymer strips
- MicroCapillary Film
- TnI
ASJC Scopus subject areas
- Bioengineering
- Chemical Engineering (miscellaneous)