Abstract
A practically simple three-component chiral derivatization protocol for determining the enantiopurity of chiral 1,2-, 1,3-, and 1,4-diols by H-1 NMR spectroscopic analysis is described. The method involves treatment with 2-formylphenylboronic acid and enantiopure alpha-methylbenzylamine to afford a mixture of diastereolsomeric iminoboronate esters whose ratio is an accurate reflection of the enantiopurity of the parent diol.
Original language | English |
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Pages (from-to) | 1971-1974 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 8 |
Issue number | 10 |
DOIs | |
Publication status | Published - 2006 |