Simple oxazolidine chiral diene ligands for enantioselective rh-catalyzed conjugate additions

N.W.G. Fairhurst; R.H. Munday; D.R. Carbery

doi:10.1055/s-0032-1318135

Simple oxazolidine chiral diene ligands for enantioselective rh-catalyzed conjugate additions

N.W.G. Fairhurst
, R.H. Munday
, D.R. Carbery

Department of Chemistry

AstraZeneca UK Ltd

Research output: Contribution to journal › Article › peer-review

9 Citations (SciVal)

304 Downloads (Pure)

Abstract

Simple oxazolidine-based chiral diene ligands, ultimately derived from serine, have been synthesized using the Seebach self-regeneration of stereocenters strategy. The ligands have been used in the enantioselective Rh-catalyzed conjugate addition of aryl boronic acids to cyclohexenone. An efficient 'in vacuo' reaction protocol has been developed as part of this study.

Original language	English
Pages (from-to)	496-498
Number of pages	3
Journal	Synlett
Volume	24
Issue number	4
Early online date	23 Jan 2013
DOIs	https://doi.org/10.1055/s-0032-1318135
Publication status	Published - 2013

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Cite this

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abstract = "Simple oxazolidine-based chiral diene ligands, ultimately derived from serine, have been synthesized using the Seebach self-regeneration of stereocenters strategy. The ligands have been used in the enantioselective Rh-catalyzed conjugate addition of aryl boronic acids to cyclohexenone. An efficient 'in vacuo' reaction protocol has been developed as part of this study. ",

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AU - Fairhurst, N.W.G.

AU - Munday, R.H.

AU - Carbery, D.R.

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Y1 - 2013

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AB - Simple oxazolidine-based chiral diene ligands, ultimately derived from serine, have been synthesized using the Seebach self-regeneration of stereocenters strategy. The ligands have been used in the enantioselective Rh-catalyzed conjugate addition of aryl boronic acids to cyclohexenone. An efficient 'in vacuo' reaction protocol has been developed as part of this study.

UR - https://www.scopus.com/pages/publications/84872688131

UR - http://dx.doi.org/10.1055/s-0032-1318135

U2 - 10.1055/s-0032-1318135

DO - 10.1055/s-0032-1318135

M3 - Article

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VL - 24

SP - 496

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ER -

Simple oxazolidine chiral diene ligands for enantioselective rh-catalyzed conjugate additions

Abstract

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