TY - JOUR
T1 - Simple chiral derivatisation protocols for NMR analysis of the enantiopurity of 1,2-diphenylethane-1,2-diamine and N-Boccyclohexane-1,2-diamine
AU - Kelly, A M
AU - Bull, S D
AU - James, T D
N1 - ID number: ISI:000255350500014
PY - 2008
Y1 - 2008
N2 - Practically simple three-component chiral derivatisation protocols for determining the enantiopurity of vicinal C-2-symmetric diamines by H-1 NMR spectroscopic analysis are described. This involves the treatment of 1,2-diphenylethane-1,2-diamine or N-Boccyclohexane-1,2-diamine with 2-formylphenylboronic acid and enantiopure BINOL, which afford mixtures of diastereoisomeric boronate esters whose ratio is an accurate reflection of the enantiopurity of the parent diamine. (C) 2008 Elsevier Ltd. All rights reserved.
AB - Practically simple three-component chiral derivatisation protocols for determining the enantiopurity of vicinal C-2-symmetric diamines by H-1 NMR spectroscopic analysis are described. This involves the treatment of 1,2-diphenylethane-1,2-diamine or N-Boccyclohexane-1,2-diamine with 2-formylphenylboronic acid and enantiopure BINOL, which afford mixtures of diastereoisomeric boronate esters whose ratio is an accurate reflection of the enantiopurity of the parent diamine. (C) 2008 Elsevier Ltd. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=39949083373&partnerID=8YFLogxK
U2 - 10.1016/j.tetasy.2008.01.026
DO - 10.1016/j.tetasy.2008.01.026
M3 - Article
SN - 0957-4166
VL - 19
SP - 489
EP - 494
JO - Tetrahedron: Asymmetry
JF - Tetrahedron: Asymmetry
IS - 4
ER -