Silk-Based Biopolymers Promise Extensive Biomedical Applications in Tissue Engineering, Drug Delivery, and BioMEMS

Amirhossein Farahani, Abbas Zarei-Hanzaki, Hamid Reza Abedi, Sara Daryoush, Zahra Delbari Ragheb, Fatemeh Mianabadi, Sahar Shahparvar, Mohammad Akrami, Ebrahim Mostafavi, Hamideh Khanbareh, Farhad R. Nezami

Research output: Contribution to journalReview articlepeer-review

6 Citations (SciVal)
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As an FDA-approved biopolymer, silk has been contemplated for a wide range of applications based on its unique merits, such as biocompatibility, biodegradability, and piezoelectricity. As silk, in both crystalline structure and amorphous state, exhibits unique physical, mechanical, and biological properties (promoting cell migration, differentiation, growth, and protein-surface interaction), it is fruitful to understand its potential applications. Sensors, actuators, and drug delivery systems are the best in case. As such, the current effort first introduces silk fibroin (SF) and delineates its characteristics. It then explores the extensive use of this biomaterial in tissue engineering approaches, in addition to its biosensor and electro-active wearable bioelectronic application. To this end, the SF application in cardiovascular, skin, cartilage, and drug delivery systems for cancer therapy and wound healing was studied precisely. Compositing any type of other variables to induce a specific application or improve any SF barriers, namely its hydrophobicity, poor electrical conductivity, or tuning its mechanical properties, especially in tissue engineering applications, has also been discussed wherever it is deemed informative.

Original languageEnglish
Pages (from-to)4559-4582
Number of pages24
JournalJournal of Polymers and the Environment
Issue number11
Early online date18 May 2023
Publication statusPublished - 30 Nov 2023

Data Availability Statement

The data that support the findings of this study were derived from the references numbered [22, 38, 42, 46, 47, 55, 64,65,66,67, 70,71,72, 84, 86, 88,89,90, 99, 101,102,103, 118].


  • Bio-MEMS
  • Bio-sensors
  • Cancer therapy
  • Diabetic diseases
  • Drug delivery systems
  • Electro-active biopolymer
  • Silk fibroin (SF)
  • Tissue engineering
  • Wearable bioelectronic
  • Wound healing

ASJC Scopus subject areas

  • Environmental Engineering
  • Polymers and Plastics
  • Materials Chemistry


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