Signalling change: signal transduction through the decades

Nancy E Hynes; Philip W Ingham; Wendell A Lim; Christopher J Marshall; Joan Massagué; Tony Pawson

doi:10.1038/nrm3581

Signalling change: signal transduction through the decades

Nancy E Hynes, Philip W Ingham, Wendell A Lim, Christopher J Marshall, Joan Massagué, Tony Pawson

Department of Life Sciences

University Psychiatric Clinics Basel

Research output: Contribution to journal › Review article › peer-review

50 Citations (SciVal)

Abstract

The past few years have marked significant anniversaries in signal transduction, including the identification of classic growth factors and morphogens, the notion of protein modification through phosphorylation and the characterization of protein interaction domains. Here, six researchers reflect on the context in which these discoveries were made, and how our concept of cell signalling has evolved during the past three decades.

Original language	English
Pages (from-to)	393-8
Number of pages	6
Journal	Nature Reviews Molecular Cell Biology
Volume	14
Issue number	6
Early online date	2 May 2013
DOIs	https://doi.org/10.1038/nrm3581
Publication status	Published - 1 Jun 2013

Keywords

Animals
Biomedical Research/history
History, 20th Century
History, 21st Century
Humans
Intercellular Signaling Peptides and Proteins/metabolism
Phosphorylation
Protein Processing, Post-Translational
Signal Transduction

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10.1038/nrm3581

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abstract = "The past few years have marked significant anniversaries in signal transduction, including the identification of classic growth factors and morphogens, the notion of protein modification through phosphorylation and the characterization of protein interaction domains. Here, six researchers reflect on the context in which these discoveries were made, and how our concept of cell signalling has evolved during the past three decades.",

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AU - Lim, Wendell A

AU - Marshall, Christopher J

AU - Massagué, Joan

AU - Pawson, Tony

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AB - The past few years have marked significant anniversaries in signal transduction, including the identification of classic growth factors and morphogens, the notion of protein modification through phosphorylation and the characterization of protein interaction domains. Here, six researchers reflect on the context in which these discoveries were made, and how our concept of cell signalling has evolved during the past three decades.

KW - Animals

KW - Biomedical Research/history

KW - History, 20th Century

KW - History, 21st Century

KW - Humans

KW - Intercellular Signaling Peptides and Proteins/metabolism

KW - Phosphorylation

KW - Protein Processing, Post-Translational

KW - Signal Transduction

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DO - 10.1038/nrm3581

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JF - Nature Reviews Molecular Cell Biology

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Signalling change: signal transduction through the decades

Abstract

Keywords

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