Signaling to extracellular signal-regulated kinase from ErbB1 kinase and protein kinase c: Feedback, heterogeneity, and gating

R.M. Perrett; R.C. Fowkes; C.J. Caunt; K. Tsaneva-Atanasova; C.G. Bowsher; C.A. McArdle

doi:10.1074/jbc.M113.455345

Signaling to extracellular signal-regulated kinase from ErbB1 kinase and protein kinase c: Feedback, heterogeneity, and gating

R.M. Perrett
, R.C. Fowkes
, C.J. Caunt
, K. Tsaneva-Atanasova
, C.G. Bowsher
, C.A. McArdle

Department of Life Sciences

Royal Veterinary College University of London
University of Bristol

Research output: Contribution to journal › Article › peer-review

18 Citations (SciVal)

217 Downloads (Pure)

Abstract

Background: The mechanisms underlying acute ERK signaling are poorly understood. Results: Feedback influences basal and acutely stimulated ERK responses but does not render signaling kinetics robust to ERK concentration. Conclusion: Acute ERK response kinetics depend on ERK concentration and activation mechanism as well as feedback. Significance: ERK responses to transient stimulation can be gated by ERK concentration, and short-term activation appears distributive rather than processive.

Original language	English
Pages (from-to)	21001-21014
Number of pages	14
Journal	Journal of Biological Chemistry
Volume	288
Issue number	29
Early online date	10 Jun 2013
DOIs	https://doi.org/10.1074/jbc.M113.455345
Publication status	Published - 19 Jul 2013

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10.1074/jbc.M113.455345

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Cite this

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AU - Perrett, R.M.

AU - Fowkes, R.C.

AU - Caunt, C.J.

AU - Tsaneva-Atanasova, K.

AU - Bowsher, C.G.

AU - McArdle, C.A.

PY - 2013/7/19

Y1 - 2013/7/19

N2 - Background: The mechanisms underlying acute ERK signaling are poorly understood. Results: Feedback influences basal and acutely stimulated ERK responses but does not render signaling kinetics robust to ERK concentration. Conclusion: Acute ERK response kinetics depend on ERK concentration and activation mechanism as well as feedback. Significance: ERK responses to transient stimulation can be gated by ERK concentration, and short-term activation appears distributive rather than processive.

AB - Background: The mechanisms underlying acute ERK signaling are poorly understood. Results: Feedback influences basal and acutely stimulated ERK responses but does not render signaling kinetics robust to ERK concentration. Conclusion: Acute ERK response kinetics depend on ERK concentration and activation mechanism as well as feedback. Significance: ERK responses to transient stimulation can be gated by ERK concentration, and short-term activation appears distributive rather than processive.

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ER -

Signaling to extracellular signal-regulated kinase from ErbB1 kinase and protein kinase c: Feedback, heterogeneity, and gating

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