Signaling to extracellular signal-regulated kinase from ErbB1 kinase and protein kinase c: Feedback, heterogeneity, and gating

R.M. Perrett, R.C. Fowkes, C.J. Caunt, K. Tsaneva-Atanasova, C.G. Bowsher, C.A. McArdle

Research output: Contribution to journalArticlepeer-review

14 Citations (Scopus)
114 Downloads (Pure)

Abstract

Background: The mechanisms underlying acute ERK signaling are poorly understood. Results: Feedback influences basal and acutely stimulated ERK responses but does not render signaling kinetics robust to ERK concentration. Conclusion: Acute ERK response kinetics depend on ERK concentration and activation mechanism as well as feedback. Significance: ERK responses to transient stimulation can be gated by ERK concentration, and short-term activation appears distributive rather than processive.
Original languageEnglish
Pages (from-to)21001-21014
Number of pages14
JournalJournal of Biological Chemistry
Volume288
Issue number29
Early online date10 Jun 2013
DOIs
Publication statusPublished - 19 Jul 2013

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