Projects per year
Abstract
Signal transduction and signal amplification are both important mechanisms used within biological signalling pathways. Inspired by this process, we have developed a signal amplification methodology that utilises the selectivity and high activity of enzymes in combination with the robustness and generality of an organometallic catalyst, achieving a hybrid biological and synthetic catalyst cascade. A proligand enzyme substrate was designed to selectively self-immolate in the presence of the enzyme to release a ligand that can bind to a metal pre-catalyst and accelerate the rate of a transfer hydrogenation reaction. Enzyme-triggered catalytic signal amplification was then applied to a range of catalyst substrates demonstrating that signal amplification and signal transduction can both be achieved through this methodology.
Original language | English |
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Pages (from-to) | 4978-4985 |
Number of pages | 8 |
Journal | Chemical Science |
Volume | 6 |
Issue number | 8 |
Early online date | 15 Jun 2015 |
DOIs | |
Publication status | Published - 1 Aug 2015 |
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Dive into the research topics of 'Signal transduction and amplification through enzyme-triggered ligand release and accelerated catalysis'. Together they form a unique fingerprint.Projects
- 1 Finished
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Enhanced Oral Delivery of Biopharmaceuticals
Mrsny, R. (PI)
15/05/14 → 14/11/14
Project: Research council
Profiles
Equipment
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MC2-Mass Spectrometry (MS)
Material and Chemical Characterisation (MC2)Facility/equipment: Technology type
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MC2- Nuclear Magnetic Resonance (NMR)
Material and Chemical Characterisation (MC2)Facility/equipment: Technology type