Signal transduction and amplification through enzyme-triggered ligand release and accelerated catalysis

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Abstract

Signal transduction and signal amplification are both important mechanisms used within biological signalling pathways. Inspired by this process, we have developed a signal amplification methodology that utilises the selectivity and high activity of enzymes in combination with the robustness and generality of an organometallic catalyst, achieving a hybrid biological and synthetic catalyst cascade. A proligand enzyme substrate was designed to selectively self-immolate in the presence of the enzyme to release a ligand that can bind to a metal pre-catalyst and accelerate the rate of a transfer hydrogenation reaction. Enzyme-triggered catalytic signal amplification was then applied to a range of catalyst substrates demonstrating that signal amplification and signal transduction can both be achieved through this methodology.

Original languageEnglish
Pages (from-to)4978-4985
Number of pages8
JournalChemical Science
Volume6
Issue number8
Early online date15 Jun 2015
DOIs
Publication statusPublished - 1 Aug 2015

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