Signal Transduction and Activation of the NADPH Oxidase in Eosinophils

Mark A. Lindsay; Mark A. Giembycz

doi:10.1590/S0074-02761997000800016

Signal Transduction and Activation of the NADPH Oxidase in Eosinophils

Mark A. Lindsay, Mark A. Giembycz

Research output: Contribution to journal › Article › peer-review

11 Citations (SciVal)

Abstract

Activation of the eosinophil NADPH oxidase and the subsequent release of toxic oxygen radicals has been implicated in the mechanism of parasite killing and inflammation. At present, little is known of the signal transduction pathway that govern agonist-induced activation of the respiratory burst and is the subject of this review. In particular, we focus on the ability of leukotrine B₄ to activate the NADPH oxidase in guinea-pig peritoneal eosinophils which can be obtained in sufficient number and purity for detailed biochemical experiments to be performed.

Original language	English
Pages (from-to)	115-123
Number of pages	9
Journal	Memorias do Instituto Oswaldo Cruz
Volume	92 SUPPL. 2
DOIs	https://doi.org/10.1590/S0074-02761997000800016
Publication status	Published - 31 Dec 1997

Keywords

Eosinophil
Leukotriene B
NADPH oxidase
Signal transduction

ASJC Scopus subject areas

Microbiology (medical)

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10.1590/S0074-02761997000800016Licence: CC BY-NC

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abstract = "Activation of the eosinophil NADPH oxidase and the subsequent release of toxic oxygen radicals has been implicated in the mechanism of parasite killing and inflammation. At present, little is known of the signal transduction pathway that govern agonist-induced activation of the respiratory burst and is the subject of this review. In particular, we focus on the ability of leukotrine B4 to activate the NADPH oxidase in guinea-pig peritoneal eosinophils which can be obtained in sufficient number and purity for detailed biochemical experiments to be performed.",

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AU - Giembycz, Mark A.

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N2 - Activation of the eosinophil NADPH oxidase and the subsequent release of toxic oxygen radicals has been implicated in the mechanism of parasite killing and inflammation. At present, little is known of the signal transduction pathway that govern agonist-induced activation of the respiratory burst and is the subject of this review. In particular, we focus on the ability of leukotrine B4 to activate the NADPH oxidase in guinea-pig peritoneal eosinophils which can be obtained in sufficient number and purity for detailed biochemical experiments to be performed.

AB - Activation of the eosinophil NADPH oxidase and the subsequent release of toxic oxygen radicals has been implicated in the mechanism of parasite killing and inflammation. At present, little is known of the signal transduction pathway that govern agonist-induced activation of the respiratory burst and is the subject of this review. In particular, we focus on the ability of leukotrine B4 to activate the NADPH oxidase in guinea-pig peritoneal eosinophils which can be obtained in sufficient number and purity for detailed biochemical experiments to be performed.

KW - Eosinophil

KW - Leukotriene B

KW - NADPH oxidase

KW - Signal transduction

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JO - Memorias do Instituto Oswaldo Cruz

JF - Memorias do Instituto Oswaldo Cruz

ER -

Signal Transduction and Activation of the NADPH Oxidase in Eosinophils

Abstract

Keywords

ASJC Scopus subject areas

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