Si-free enolate Claisen rearrangements of enamido substrates

Wesley R R Harker, E L Carswell, David R Carbery

Research output: Contribution to journalArticle

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Abstract

alpha-Alkyl beta-amino esters are available in high diastereoselectivity through a silicon-free Claisen enolate [3,3]-sigmatropic rearrangement of enamide esters. Optimisation studies have probed the crucial role of the initial enolisation and the nature of the enamide N-centre. The demonstration of chirality transfer and the formation of beta-proline systems, is also presented.
LanguageEnglish
Pages1406-1410
Number of pages5
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number7
DOIs
StatusPublished - 2012

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Si-free enolate Claisen rearrangements of enamido substrates. / Harker, Wesley R R; Carswell, E L; Carbery, David R.

In: Organic and Biomolecular Chemistry, Vol. 10, No. 7, 2012, p. 1406-1410.

Research output: Contribution to journalArticle

Harker, Wesley R R ; Carswell, E L ; Carbery, David R. / Si-free enolate Claisen rearrangements of enamido substrates. In: Organic and Biomolecular Chemistry. 2012 ; Vol. 10, No. 7. pp. 1406-1410
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