Short-term Repeat Magnetic Resonance Imaging Scans in Suspected Early Axial Spondyloarthritis Are Clinically Relevant Only in HLA-B27-positive Male Subjects

Raj Sengupta, Helena Marzo-Ortega, Dennis McGonagle, Alison Wadeley, Alexander N Bennett, British Society for Spondyloarthritis

Research output: Contribution to journalArticle

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Abstract

OBJECTIVE: Our study investigated the natural history of magnetic resonance imaging (MRI)-determined bone marrow edema over a 12-week period in individuals with suspected axial spondyloarthritis.

METHODS: There were 109 MRI scans performed on 30 patients who fulfilled the Assessment of Spondyloarthritis international Society inflammatory back pain criteria at baseline and at 4, 8, and 12 weeks.

RESULTS: There were 29 patients who completed the study. Only 4 (14%) patients changed from MRI-negative to MRI-positive (all HLA-B27-positive, OR 2.74). Three of 7 (43%) male HLA-B27-positive patients, 1 of 8 (12.5%) HLA-B27-positive female patients, and no HLA-B27-negative patients changed from MRI- negative to -positive.

CONCLUSION: Repeat MRI scans within a 12-week period should be considered in HLA-B27-positive males.

Original languageEnglish
Pages (from-to)202-205
Number of pages4
JournalThe Journal of Rheumatology
Volume45
Issue number2
DOIs
Publication statusPublished - 1 Feb 2018

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HLA-B27 Antigen
Magnetic Resonance Imaging
Back Pain
Natural History
Edema
Bone Marrow

Keywords

  • Journal Article

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Short-term Repeat Magnetic Resonance Imaging Scans in Suspected Early Axial Spondyloarthritis Are Clinically Relevant Only in HLA-B27-positive Male Subjects. / Sengupta, Raj; Marzo-Ortega, Helena; McGonagle, Dennis; Wadeley, Alison; Bennett, Alexander N; British Society for Spondyloarthritis.

In: The Journal of Rheumatology, Vol. 45, No. 2, 01.02.2018, p. 202-205.

Research output: Contribution to journalArticle

Sengupta, Raj ; Marzo-Ortega, Helena ; McGonagle, Dennis ; Wadeley, Alison ; Bennett, Alexander N ; British Society for Spondyloarthritis. / Short-term Repeat Magnetic Resonance Imaging Scans in Suspected Early Axial Spondyloarthritis Are Clinically Relevant Only in HLA-B27-positive Male Subjects. In: The Journal of Rheumatology. 2018 ; Vol. 45, No. 2. pp. 202-205.
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