Short-term Repeat Magnetic Resonance Imaging Scans in Suspected Early Axial Spondyloarthritis Are Clinically Relevant Only in HLA-B27-positive Male Subjects

Raj Sengupta; Helena Marzo-Ortega; Dennis McGonagle; Alison Wadeley; Alexander N Bennett; British Society for Spondyloarthritis

doi:10.3899/jrheum.170171

Short-term Repeat Magnetic Resonance Imaging Scans in Suspected Early Axial Spondyloarthritis Are Clinically Relevant Only in HLA-B27-positive Male Subjects

Raj Sengupta, Helena Marzo-Ortega, Dennis McGonagle, Alison Wadeley, Alexander N Bennett, British Society for Spondyloarthritis

Department of Life Sciences

Royal National Hospital for Rheumatic Diseases

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Abstract

OBJECTIVE: Our study investigated the natural history of magnetic resonance imaging (MRI)-determined bone marrow edema over a 12-week period in individuals with suspected axial spondyloarthritis.

METHODS: There were 109 MRI scans performed on 30 patients who fulfilled the Assessment of Spondyloarthritis international Society inflammatory back pain criteria at baseline and at 4, 8, and 12 weeks.

RESULTS: There were 29 patients who completed the study. Only 4 (14%) patients changed from MRI-negative to MRI-positive (all HLA-B27-positive, OR 2.74). Three of 7 (43%) male HLA-B27-positive patients, 1 of 8 (12.5%) HLA-B27-positive female patients, and no HLA-B27-negative patients changed from MRI- negative to -positive.

CONCLUSION: Repeat MRI scans within a 12-week period should be considered in HLA-B27-positive males.

Original language	English
Pages (from-to)	202-205
Number of pages	4
Journal	The Journal of Rheumatology
Volume	45
Issue number	2
DOIs	https://doi.org/10.3899/jrheum.170171
Publication status	Published - 1 Feb 2018

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10.3899/jrheum.170171

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This is a pre-copyediting, author-produced PDF of an article accepted for publication in The Journal of Rheumatology following peer review. The definitive publisher-authenticated version "Short-term Repeat Magnetic Resonance Imaging Scans in Suspected Early Axial Spondyloarthritis Are Clinically Relevant Only in HLA-B27–positive Male Subjects" by Raj Sengupta, Helena Marzo-Ortega, Dennis McGonagle, Alison Wadeley, Alexander N. Bennett, on behalf of the British Society for Spondyloarthritis; in The Journal of Rheumatology Feb 2018, 45 (2) 202-205; DOI: 10.3899/jrheum.170171 is available online at: https://doi.org/10.3899/jrheum.170171.
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abstract = "OBJECTIVE: Our study investigated the natural history of magnetic resonance imaging (MRI)-determined bone marrow edema over a 12-week period in individuals with suspected axial spondyloarthritis.METHODS: There were 109 MRI scans performed on 30 patients who fulfilled the Assessment of Spondyloarthritis international Society inflammatory back pain criteria at baseline and at 4, 8, and 12 weeks.RESULTS: There were 29 patients who completed the study. Only 4 (14%) patients changed from MRI-negative to MRI-positive (all HLA-B27-positive, OR 2.74). Three of 7 (43%) male HLA-B27-positive patients, 1 of 8 (12.5%) HLA-B27-positive female patients, and no HLA-B27-negative patients changed from MRI- negative to -positive.CONCLUSION: Repeat MRI scans within a 12-week period should be considered in HLA-B27-positive males.",

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AU - McGonagle, Dennis

AU - Wadeley, Alison

AU - Bennett, Alexander N

AU - British Society for Spondyloarthritis

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AB - OBJECTIVE: Our study investigated the natural history of magnetic resonance imaging (MRI)-determined bone marrow edema over a 12-week period in individuals with suspected axial spondyloarthritis.METHODS: There were 109 MRI scans performed on 30 patients who fulfilled the Assessment of Spondyloarthritis international Society inflammatory back pain criteria at baseline and at 4, 8, and 12 weeks.RESULTS: There were 29 patients who completed the study. Only 4 (14%) patients changed from MRI-negative to MRI-positive (all HLA-B27-positive, OR 2.74). Three of 7 (43%) male HLA-B27-positive patients, 1 of 8 (12.5%) HLA-B27-positive female patients, and no HLA-B27-negative patients changed from MRI- negative to -positive.CONCLUSION: Repeat MRI scans within a 12-week period should be considered in HLA-B27-positive males.

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Short-term Repeat Magnetic Resonance Imaging Scans in Suspected Early Axial Spondyloarthritis Are Clinically Relevant Only in HLA-B27-positive Male Subjects

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