Seven-transmembrane receptor signalling and ERK compartmentalization

Christopher J Caunt, A R Finch, K R Sedgley, C A McArdle

Research output: Contribution to journalArticlepeer-review

71 Citations (Scopus)

Abstract

Vast numbers of extracellular signalling molecules exert effects on their target cells by activation of a relatively limited number of mitogen-activated protein kinase (MAPK) cascades, raising the question of how specificity is achieved. To a large extent, this appears to be attributable to differences in kinetics and compartmentalization of MAPK protein activation that are dictated by MAPK-associated proteins serving as scaffolds, anchors, activators or effectors. Here, we review spatiotemporal aspects of signalling via the Ras-Raf-extracellular signal-regulated kinase pathway, emphasizing recent work on roles of arrestins as scaffolds and transducers for seven transmembrane receptor signalling.
Original languageEnglish
Pages (from-to)276-283
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume17
Issue number7
DOIs
Publication statusPublished - 2006

Fingerprint

Dive into the research topics of 'Seven-transmembrane receptor signalling and ERK compartmentalization'. Together they form a unique fingerprint.

Cite this