Seven-transmembrane receptor signalling and ERK compartmentalization

Christopher J Caunt, A R Finch, K R Sedgley, C A McArdle

Research output: Contribution to journalArticle

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Abstract

Vast numbers of extracellular signalling molecules exert effects on their target cells by activation of a relatively limited number of mitogen-activated protein kinase (MAPK) cascades, raising the question of how specificity is achieved. To a large extent, this appears to be attributable to differences in kinetics and compartmentalization of MAPK protein activation that are dictated by MAPK-associated proteins serving as scaffolds, anchors, activators or effectors. Here, we review spatiotemporal aspects of signalling via the Ras-Raf-extracellular signal-regulated kinase pathway, emphasizing recent work on roles of arrestins as scaffolds and transducers for seven transmembrane receptor signalling.
LanguageEnglish
Pages276-283
Number of pages8
JournalTrends in Endocrinology and Metabolism
Volume17
Issue number7
DOIs
StatusPublished - 2006

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Mitogen-Activated Protein Kinases
Arrestins
Extracellular Signal-Regulated MAP Kinases
Transducers
Proteins

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Caunt, C. J., Finch, A. R., Sedgley, K. R., & McArdle, C. A. (2006). Seven-transmembrane receptor signalling and ERK compartmentalization. DOI: 10.1016/j.tem.2006.07.008

Seven-transmembrane receptor signalling and ERK compartmentalization. / Caunt, Christopher J; Finch, A R; Sedgley, K R; McArdle, C A.

In: Trends in Endocrinology and Metabolism, Vol. 17, No. 7, 2006, p. 276-283.

Research output: Contribution to journalArticle

Caunt, CJ, Finch, AR, Sedgley, KR & McArdle, CA 2006, 'Seven-transmembrane receptor signalling and ERK compartmentalization' Trends in Endocrinology and Metabolism, vol. 17, no. 7, pp. 276-283. DOI: 10.1016/j.tem.2006.07.008
Caunt CJ, Finch AR, Sedgley KR, McArdle CA. Seven-transmembrane receptor signalling and ERK compartmentalization. Trends in Endocrinology and Metabolism. 2006;17(7):276-283. Available from, DOI: 10.1016/j.tem.2006.07.008
Caunt, Christopher J ; Finch, A R ; Sedgley, K R ; McArdle, C A. / Seven-transmembrane receptor signalling and ERK compartmentalization. In: Trends in Endocrinology and Metabolism. 2006 ; Vol. 17, No. 7. pp. 276-283
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