Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

Kai Cheng Yan; Adam C. Sedgwick; Yi Zang; Guo Rong Chen; Xiao Peng He; Jia Li; Juyoung Yoon; Tony D. James

doi:10.1002/smtd.201900013

Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

Kai Cheng Yan, Adam C. Sedgwick, Yi Zang, Guo Rong Chen, Xiao Peng He, Jia Li, Juyoung Yoon, Tony D. James

Research output: Contribution to journal › Review article › peer-review

75 Citations (SciVal)

Abstract

Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in the damage of tissues and cells. Therefore, ROS have been implicated in an array of diseases including cancer, inflammation, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Owing to the simplicity, sensitivity, and selectivity of fluorescence-based strategies, many small-molecular sensors or imaging agents have been developed to sense and visualize ROS both in vitro and in vivo. Likewise, activatable drug delivery and prodrug systems that can be triggered by ROS for disease theranostics (diagnostic and therapeutic combined) have been developed. Herein, recently developed fluorescence-based sensing and imaging agents for the detection of ROS both intracellularly and in vivo are summarized. In addition, drug delivery, which require activation by ROS to achieve disease theranostics is also discussed.

Original language	English
Article number	1900013
Journal	Small Methods
Volume	3
Issue number	7
Early online date	26 Apr 2019
DOIs	https://doi.org/10.1002/smtd.201900013
Publication status	Published - 8 Jul 2019

Funding

K.-C.Y., Y.Z., G.-R.C., J.L., and X.-P.H. thank the National Natural Science Foundation of China (Grant Nos. 91853201, 21722801, 21776078, 81673489, and 81125023), the Shanghai Municipal Science and Technology Major Project (Grant No. 2018SHZDZX03) and Internation Cooperation Project (Grant No. 16430724100), the Programme of Introducing Talents of Discipline to Universities (B16017), and the K. C. Wong Education Foundation and the Fundamental Research Funds for the Central Universities (222201717003) for generous financial support. T.D.J. wishes to thank the Royal Society for a Wolfson Research Merit Award. J.Y. thanks the National Research Foundation of Korea (NRF), which was funded by the Korea government (MSIP) (Grant No. 2012R1A3A2048814).

Keywords

fluorescence
imaging agents
ROS
sensors
theranostics

ASJC Scopus subject areas

General Materials Science
General Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/smtd.201900013Licence: CC BY

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title = "Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases",

abstract = "Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in the damage of tissues and cells. Therefore, ROS have been implicated in an array of diseases including cancer, inflammation, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Owing to the simplicity, sensitivity, and selectivity of fluorescence-based strategies, many small-molecular sensors or imaging agents have been developed to sense and visualize ROS both in vitro and in vivo. Likewise, activatable drug delivery and prodrug systems that can be triggered by ROS for disease theranostics (diagnostic and therapeutic combined) have been developed. Herein, recently developed fluorescence-based sensing and imaging agents for the detection of ROS both intracellularly and in vivo are summarized. In addition, drug delivery, which require activation by ROS to achieve disease theranostics is also discussed.",

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AU - He, Xiao Peng

AU - Li, Jia

AU - Yoon, Juyoung

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AB - Reactive oxygen species (ROS) consist of a diverse range of oxidative small molecular ions and free radicals that are produced throughout the body during certain biological processes. Due to their high reactivity, these molecules result in the damage of tissues and cells. Therefore, ROS have been implicated in an array of diseases including cancer, inflammation, and neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Owing to the simplicity, sensitivity, and selectivity of fluorescence-based strategies, many small-molecular sensors or imaging agents have been developed to sense and visualize ROS both in vitro and in vivo. Likewise, activatable drug delivery and prodrug systems that can be triggered by ROS for disease theranostics (diagnostic and therapeutic combined) have been developed. Herein, recently developed fluorescence-based sensing and imaging agents for the detection of ROS both intracellularly and in vivo are summarized. In addition, drug delivery, which require activation by ROS to achieve disease theranostics is also discussed.

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Sensors, Imaging Agents, and Theranostics to Help Understand and Treat Reactive Oxygen Species Related Diseases

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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