Abstract

Since the discovery of protein kinase activity in 1954, close to 600 kinases have been discovered that have crucial roles in cell physiology. In several pathological conditions, aberrant protein kinase activity leads to abnormal cell and tissue physiology. Therefore, protein kinase inhibitors are investigated as potential treatments for several diseases, including dementia, diabetes, cancer and autoimmune and cardiovascular disease. Modern semiconductor technology has recently been applied to accelerate the discovery of novel protein kinase inhibitors that could become the standard-of-care drugs of tomorrow. Here, we describe current techniques and novel applications of semiconductor technologies in protein kinase inhibitor drug discovery.
Original languageEnglish
Pages (from-to)204-209
Number of pages6
JournalDrug Discovery Today
Volume22
Issue number2
Early online date22 Oct 2016
DOIs
Publication statusPublished - Feb 2017

Fingerprint

Semiconductors
Drug Discovery
Protein Kinase Inhibitors
Protein Kinases
Cell Physiological Phenomena
Technology
Research
Standard of Care
Autoimmune Diseases
Dementia
Cardiovascular Diseases
Phosphotransferases
Pharmaceutical Preparations
Neoplasms

Keywords

  • Semiconductor
  • protein kinase
  • Biosensors

Cite this

Semiconductor technology in protein kinase research and drug discovery : sensing a revolution. / Bhalla, Nikhil; Di Lorenzo, Mirella; Estrela, Pedro; Pula, Giordano.

In: Drug Discovery Today, Vol. 22, No. 2, 02.2017, p. 204-209.

Research output: Contribution to journalArticle

@article{701b54276cfc4eaaba744f5ef3377a1a,
title = "Semiconductor technology in protein kinase research and drug discovery: sensing a revolution",
abstract = "Since the discovery of protein kinase activity in 1954, close to 600 kinases have been discovered that have crucial roles in cell physiology. In several pathological conditions, aberrant protein kinase activity leads to abnormal cell and tissue physiology. Therefore, protein kinase inhibitors are investigated as potential treatments for several diseases, including dementia, diabetes, cancer and autoimmune and cardiovascular disease. Modern semiconductor technology has recently been applied to accelerate the discovery of novel protein kinase inhibitors that could become the standard-of-care drugs of tomorrow. Here, we describe current techniques and novel applications of semiconductor technologies in protein kinase inhibitor drug discovery.",
keywords = "Semiconductor, protein kinase, Biosensors",
author = "Nikhil Bhalla and {Di Lorenzo}, Mirella and Pedro Estrela and Giordano Pula",
year = "2017",
month = "2",
doi = "10.1016/j.drudis.2016.10.006",
language = "English",
volume = "22",
pages = "204--209",
journal = "Drug Discovery Today",
issn = "1359-6446",
publisher = "Elsevier",
number = "2",

}

TY - JOUR

T1 - Semiconductor technology in protein kinase research and drug discovery

T2 - sensing a revolution

AU - Bhalla, Nikhil

AU - Di Lorenzo, Mirella

AU - Estrela, Pedro

AU - Pula, Giordano

PY - 2017/2

Y1 - 2017/2

N2 - Since the discovery of protein kinase activity in 1954, close to 600 kinases have been discovered that have crucial roles in cell physiology. In several pathological conditions, aberrant protein kinase activity leads to abnormal cell and tissue physiology. Therefore, protein kinase inhibitors are investigated as potential treatments for several diseases, including dementia, diabetes, cancer and autoimmune and cardiovascular disease. Modern semiconductor technology has recently been applied to accelerate the discovery of novel protein kinase inhibitors that could become the standard-of-care drugs of tomorrow. Here, we describe current techniques and novel applications of semiconductor technologies in protein kinase inhibitor drug discovery.

AB - Since the discovery of protein kinase activity in 1954, close to 600 kinases have been discovered that have crucial roles in cell physiology. In several pathological conditions, aberrant protein kinase activity leads to abnormal cell and tissue physiology. Therefore, protein kinase inhibitors are investigated as potential treatments for several diseases, including dementia, diabetes, cancer and autoimmune and cardiovascular disease. Modern semiconductor technology has recently been applied to accelerate the discovery of novel protein kinase inhibitors that could become the standard-of-care drugs of tomorrow. Here, we describe current techniques and novel applications of semiconductor technologies in protein kinase inhibitor drug discovery.

KW - Semiconductor

KW - protein kinase

KW - Biosensors

UR - http://dx.doi.org/10.1016/j.drudis.2016.10.006

U2 - 10.1016/j.drudis.2016.10.006

DO - 10.1016/j.drudis.2016.10.006

M3 - Article

VL - 22

SP - 204

EP - 209

JO - Drug Discovery Today

JF - Drug Discovery Today

SN - 1359-6446

IS - 2

ER -