Self-assembled complex formulations of lipid-aminoglycoside conjugates

Nanoparticles for efficient gene and siRNA delivery

Hassan M Ghonaim, Y X Cheng, Charareh Pourzand, Ian Blagbrough

Research output: Contribution to journalArticle

Abstract

We are designing and developing lipid-polyamines based upon aminoglycoside cationic head-groups linked to a lipid moiety, e.g. cholesterol, for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression. The conjugation of neomycin B to cholesterol provides an "intelligent" material which may well overcome problems found in poly-nucleic acid delivery.
Original languageEnglish
Pages (from-to)1295-1296
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume62
Issue number10
DOIs
Publication statusPublished - Oct 2010
EventUK PharmSci 2010 - The Science of Medicines - , UK United Kingdom
Duration: 1 Sep 20103 Sep 2010

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Aminoglycosides
Nanoparticles
Small Interfering RNA
Framycetin
Cholesterol
Lipids
Polyamines
Genetic Therapy
Nucleic Acids
Genes
Head
Gene Expression

Cite this

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AU - Pourzand, Charareh

AU - Blagbrough, Ian

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AB - We are designing and developing lipid-polyamines based upon aminoglycoside cationic head-groups linked to a lipid moiety, e.g. cholesterol, for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression. The conjugation of neomycin B to cholesterol provides an "intelligent" material which may well overcome problems found in poly-nucleic acid delivery.

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