Self-assembled complex formulations of lipid-aminoglycoside conjugates: Nanoparticles for efficient gene and siRNA delivery

Hassan M Ghonaim; Y X Cheng; Charareh Pourzand; Ian Blagbrough

doi:10.1111/j.2042-7158.2010.01178.x

Self-assembled complex formulations of lipid-aminoglycoside conjugates: Nanoparticles for efficient gene and siRNA delivery

Hassan M Ghonaim, Y X Cheng, Charareh Pourzand, Ian Blagbrough

Department of Life Sciences

Research output: Contribution to journal › Article

3 Citations (SciVal)

Abstract

We are designing and developing lipid-polyamines based upon aminoglycoside cationic head-groups linked to a lipid moiety, e.g. cholesterol, for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression. The conjugation of neomycin B to cholesterol provides an "intelligent" material which may well overcome problems found in poly-nucleic acid delivery.

Original language	English
Pages (from-to)	1295-1296
Number of pages	2
Journal	Journal of Pharmacy and Pharmacology
Volume	62
Issue number	10
DOIs	https://doi.org/10.1111/j.2042-7158.2010.01178.x
Publication status	Published - Oct 2010
Event	UK PharmSci 2010 - The Science of Medicines - , UK United Kingdom Duration: 1 Sept 2010 → 3 Sept 2010

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abstract = "We are designing and developing lipid-polyamines based upon aminoglycoside cationic head-groups linked to a lipid moiety, e.g. cholesterol, for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression. The conjugation of neomycin B to cholesterol provides an {"}intelligent{"} material which may well overcome problems found in poly-nucleic acid delivery.",

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AU - Cheng, Y X

AU - Pourzand, Charareh

AU - Blagbrough, Ian

PY - 2010/10

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AB - We are designing and developing lipid-polyamines based upon aminoglycoside cationic head-groups linked to a lipid moiety, e.g. cholesterol, for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression. The conjugation of neomycin B to cholesterol provides an "intelligent" material which may well overcome problems found in poly-nucleic acid delivery.

UR - http://dx.doi.org/10.1111/j.2042-7158.2010.01178.x

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JF - Journal of Pharmacy and Pharmacology

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Y2 - 1 September 2010 through 3 September 2010

ER -

Self-assembled complex formulations of lipid-aminoglycoside conjugates: Nanoparticles for efficient gene and siRNA delivery

Abstract

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