We are designing and developing lipid-polyamines based upon aminoglycoside cationic head-groups linked to a lipid moiety, e.g. cholesterol, for the efficient delivery of genes for gene therapy, and also for the delivery of siRNA to knock-down gene expression. The conjugation of neomycin B to cholesterol provides an "intelligent" material which may well overcome problems found in poly-nucleic acid delivery.
|Number of pages||2|
|Journal||Journal of Pharmacy and Pharmacology|
|Publication status||Published - Oct 2010|
|Event||UK PharmSci 2010 - The Science of Medicines - , UK United Kingdom|
Duration: 1 Sep 2010 → 3 Sep 2010
Ghonaim, H. M., Cheng, Y. X., Pourzand, C., & Blagbrough, I. (2010). Self-assembled complex formulations of lipid-aminoglycoside conjugates: Nanoparticles for efficient gene and siRNA delivery. Journal of Pharmacy and Pharmacology, 62(10), 1295-1296. https://doi.org/10.1111/j.2042-7158.2010.01178.x