Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

Lynne H. Thomas; Craig Wales; Chick C. Wilson

doi:10.1039/c6cc01027j

Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

Lynne H. Thomas
, Craig Wales
, Chick C. Wilson

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

36 Citations (SciVal)

Abstract

A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multi-component environment. Previously unknown solvates have also been synthesised by this method.

Original language	English
Pages (from-to)	7372-7375
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	46
DOIs	https://doi.org/10.1039/c6cc01027j
Publication status	Published - 11 Jun 2016

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10.1039/c6cc01027jLicence: CC BY

http://dx.doi.org/10.1039/c6cc01027jLicence: CC BY

Cite this

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title = "Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes",

abstract = "A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multi-component environment. Previously unknown solvates have also been synthesised by this method.",

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N2 - A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multi-component environment. Previously unknown solvates have also been synthesised by this method.

AB - A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multi-component environment. Previously unknown solvates have also been synthesised by this method.

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Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

Abstract

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Supporting Research Excellence in Chemistry at the University of Bath through Provision of Key Equipment Enhancements

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Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

Abstract

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Supporting Research Excellence in Chemistry at the University of Bath through Provision of Key Equipment Enhancements

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