Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

Lynne H. Thomas; Craig Wales; Chick C. Wilson

doi:10.1039/c6cc01027j

Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

Lynne H. Thomas, Craig Wales, Chick C. Wilson

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

33 Citations (SciVal)

Abstract

A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multi-component environment. Previously unknown solvates have also been synthesised by this method.

Original language	English
Pages (from-to)	7372-7375
Number of pages	4
Journal	Chemical Communications
Volume	52
Issue number	46
DOIs	https://doi.org/10.1039/c6cc01027j
Publication status	Published - 11 Jun 2016

Access to Document

10.1039/c6cc01027jLicence: CC BY

http://dx.doi.org/10.1039/c6cc01027jLicence: CC BY

Cite this

@article{9fdae4000006406aa8bfe294fdd8e03d,

title = "Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes",

abstract = "A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multi-component environment. Previously unknown solvates have also been synthesised by this method.",

author = "Thomas, {Lynne H.} and Craig Wales and Wilson, {Chick C.}",

year = "2016",

month = jun,

day = "11",

doi = "10.1039/c6cc01027j",

language = "English",

volume = "52",

pages = "7372--7375",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "46",

}

TY - JOUR

T1 - Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

AU - Thomas, Lynne H.

AU - Wales, Craig

AU - Wilson, Chick C.

PY - 2016/6/11

Y1 - 2016/6/11

N2 - A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multi-component environment. Previously unknown solvates have also been synthesised by this method.

AB - A transferable, simple, method for producing previously elusive and novel polymorphic forms of important active pharmaceutical ingredients (APIs; paracetamol (acetaminophen), piroxicam and piracetam) is demonstrated. Nitrogen heterocyclic co-molecules are employed to influence the self-assembly crystallisation process in a multi-component environment. Previously unknown solvates have also been synthesised by this method.

UR - http://www.scopus.com/inward/record.url?scp=84973307778&partnerID=8YFLogxK

UR - http://dx.doi.org/10.1039/c6cc01027j

U2 - 10.1039/c6cc01027j

DO - 10.1039/c6cc01027j

M3 - Article

AN - SCOPUS:84973307778

SN - 1359-7345

VL - 52

SP - 7372

EP - 7375

JO - Chemical Communications

JF - Chemical Communications

IS - 46

ER -

Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

Abstract

Access to Document

Other files and links

Fingerprint

Supporting Research Excellence in Chemistry at the University of Bath through Provision of Key Equipment Enhancements

Cite this

Selective preparation of elusive and alternative single component polymorphic solid forms through multi-component crystallisation routes

Abstract

Access to Document

Other files and links

Fingerprint

Projects

Supporting Research Excellence in Chemistry at the University of Bath through Provision of Key Equipment Enhancements

Cite this